{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:14:08Z","timestamp":1791296048402,"version":"4.1.0"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5678","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2004,6,18]]},"abstract":"<jats:p>\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    , the cause of food poisoning and typhoid fever, induces actin cytoskeleton rearrangements and membrane ruffling to gain access into nonphagocytic cells, where it can replicate and avoid innate immune defenses. Here, we found that SopB, a phosphoinositide phosphatase that is delivered into host cells by a type III secretion system, was essential for the establishment of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    's intracellular replicative niche. SopB mediated the formation of spacious phagosomes following bacterial entry and was responsible for maintaining high levels of phosphatidylinositol-three-phosphate [PtdIns(3)P] in the membrane of the bacteria-containing vacuoles. Absence of SopB caused a significant defect in the maturation of the\n                    <jats:italic>Salmonella<\/jats:italic>\n                    -containing vacuole and impaired bacterial intracellular growth.\n                  <\/jats:p>","DOI":"10.1126\/science.1098188","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T16:53:33Z","timestamp":1087491213000},"page":"1805-1807","source":"Crossref","is-referenced-by-count":275,"title":["<i>Salmonella<\/i>\n                    Modulates Vesicular Traffic by Altering Phosphoinositide Metabolism"],"prefix":"10.1126","volume":"304","author":[{"given":"Lorraine D.","family":"Hernandez","sequence":"first","affiliation":[{"name":"Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA."},{"name":"Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Hueffer","sequence":"additional","affiliation":[{"name":"Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA."},{"name":"Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus R.","family":"Wenk","sequence":"additional","affiliation":[{"name":"Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA."},{"name":"Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Gala\u0301n","sequence":"additional","affiliation":[{"name":"Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA."},{"name":"Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.8754"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.17.1.53"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.2.601"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.10.4641-4645.1994"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.1999.00003.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01490-3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.16.4394"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb02197.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2003.00118.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00294.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2002.00170.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.13.3235"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1996.tb02497.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.22.10544"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.129.1.81"},{"key":"e_1_3_2_17_2","first-page":"227","volume":"2","year":"1993","unstructured":"F. Garcia-del Portillo, M. B. Zwick, K. Y. Leung, B. B. Finlay, Infect. Agents Dis.2, 227 (1993).","journal-title":"Infect. Agents Dis."},{"key":"e_1_3_2_18_2","first-page":"1903","volume":"25","year":"1997","unstructured":"E. E. Galyovet al., Mol. Microbiol.25, 1903 (1997).","journal-title":"Mol. 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Gal\u00e1n unpublished results."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00856-1"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110399200"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00486-9"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb00450.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt837"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02356-0"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81442-7"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81707-9"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.01-10-0498"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-05-0297"},{"key":"e_1_3_2_39_2","unstructured":"We thank W. Mothes for useful discussions and members of the Gal\u00e1n laboratory for critical reading of this manuscript. This work was supported by a fellowship from the Damon Runyon\u2013Walter Winchell Foundation (L.D.H.) and by Public Health Service Grant #AI055472 from the National Institutes of Health (J.E.G.)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1098188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T23:19:20Z","timestamp":1704842360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1098188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,18]]},"references-count":38,"journal-issue":{"issue":"5678","published-print":{"date-parts":[[2004,6,18]]}},"alternative-id":["10.1126\/science.1098188"],"URL":"https:\/\/doi.org\/10.1126\/science.1098188","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,18]]}}}