{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:19:43Z","timestamp":1791944383328,"version":"4.3.4"},"reference-count":20,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5701","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2004,11,26]]},"abstract":"<jats:p>\n                    Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow\u2013derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL\/6 mice with\n                    <jats:italic>Helicobacter<\/jats:italic>\n                    , a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.\n                  <\/jats:p>","DOI":"10.1126\/science.1099513","type":"journal-article","created":{"date-parts":[[2004,11,26]],"date-time":"2004-11-26T09:42:48Z","timestamp":1101462168000},"page":"1568-1571","source":"Crossref","is-referenced-by-count":954,"title":["Gastric Cancer Originating from Bone Marrow-Derived Cells"],"prefix":"10.1126","volume":"306","author":[{"given":"JeanMarie","family":"Houghton","sequence":"first","affiliation":[{"name":"Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Epithelial Biology Program, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan."},{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"The Veterans Administration Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calin","family":"Stoicov","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Epithelial Biology Program, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan."},{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"The Veterans Administration Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiyo","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Epithelial Biology Program, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan."},{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"The Veterans Administration Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlin B.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Epithelial Biology Program, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan."},{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"The Veterans Administration Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Epithelial Biology Program, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan."},{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"The Veterans Administration Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanchen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Epithelial Biology Program, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan."},{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"The Veterans Administration Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Epithelial Biology Program, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan."},{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"The Veterans Administration Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Epithelial Biology Program, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan."},{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"The Veterans Administration Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Goldenring","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Epithelial Biology Program, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan."},{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"The Veterans Administration Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Epithelial Biology Program, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan."},{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"The Veterans Administration Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70581-5"},{"key":"e_1_3_2_4_2","first-page":"369","volume":"105","year":"2002","unstructured":"D. S. Krause et al., Cell105, 369 (2002).","journal-title":"Cell"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00870"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/86439"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00208-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01078-4"},{"key":"e_1_3_2_9_2","first-page":"696","volume":"62","year":"2002","unstructured":"J. G. Fox et al., Cancer Res.62, 696 (2002).","journal-title":"Cancer Res."},{"key":"e_1_3_2_10_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_2_11_2","first-page":"639","volume":"79","year":"1999","unstructured":"P. H. Schmidt et al., Lab. Invest.79, 639 (1999).","journal-title":"Lab. Invest."},{"key":"e_1_3_2_12_2","first-page":"1080","volume":"118","year":"2002","unstructured":"J. R. Goldenring et al., Gastroenterology118, 1080 (2002).","journal-title":"Gastroenterology"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50094"},{"key":"e_1_3_2_14_2","first-page":"271","volume":"33","year":"2001","unstructured":"A. D. Clouston, Pathology33, 271 (2001).","journal-title":"Pathology"},{"key":"e_1_3_2_15_2","first-page":"942","volume":"63","year":"2003","unstructured":"J. G. Fox et al., Cancer Res.63, 942 (2003).","journal-title":"Cancer Res."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm755"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.7.3671"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.298.5600.1869"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.299.5609.1002"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207651"},{"key":"e_1_3_2_21_2","unstructured":"We thank K. Cormier and the Division of Comparative Medicine histology lab for technical support and expertise in IHC and D. Altieri and E. Kurt-Jones for their helpful comments and suggestions. Supported by NIH grants K22 CA90518 (J.H.) RO1 CA87958 (T.C.W. and J.G.F.) RO1 DK58889 (T.C.W.) and a VA Merit Review and Vanderbilt GI SPORE 1P50 CA95103 (J.R.G.)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1099513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T23:29:06Z","timestamp":1704842946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1099513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,26]]},"references-count":20,"journal-issue":{"issue":"5701","published-print":{"date-parts":[[2004,11,26]]}},"alternative-id":["10.1126\/science.1099513"],"URL":"https:\/\/doi.org\/10.1126\/science.1099513","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1022772.264705","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1022772.261680","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,26]]}}}