{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:58:37Z","timestamp":1791298717901,"version":"4.1.0"},"reference-count":24,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5692","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2004,9,24]]},"abstract":"<jats:p>\n            We present the genomic sequence of\n            <jats:italic>Legionella pneumophila<\/jats:italic>\n            , the bacterial agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45\u00e2\u0080\u0093kilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for\n            <jats:italic>Legionella<\/jats:italic>\n            's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets.\n          <\/jats:p>","DOI":"10.1126\/science.1099776","type":"journal-article","created":{"date-parts":[[2004,9,23]],"date-time":"2004-09-23T20:34:13Z","timestamp":1095971653000},"page":"1966-1968","source":"Crossref","is-referenced-by-count":429,"title":["The Genomic Sequence of the Accidental Pathogen\n            <i>Legionella pneumophila<\/i>"],"prefix":"10.1126","volume":"305","author":[{"given":"Minchen","family":"Chien","sequence":"first","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Morozova","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shundi","family":"Shi","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huitao","family":"Sheng","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn M.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gifty","family":"Asamani","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra","family":"Hill","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Nuara","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Feder","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Rineer","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Steshenko","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha H.","family":"Park","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elita","family":"Teplitskaya","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Pampou","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthi","family":"Georghiou","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.-Chun","family":"Chou","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Iannuccilli","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Ulz","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Geringer-Sameth","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis","family":"Goldsberry","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Morozov","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart G.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Segal","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Qu","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Rzhetsky","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peisen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eftihia","family":"Cayanis","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J.","family":"De Jong","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyue","family":"Ju","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Kalachikov","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Shuman","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Russo","sequence":"additional","affiliation":[{"name":"Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France."},{"name":"BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA."},{"name":"Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA."},{"name":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"1189","volume":"297","year":"1977","unstructured":"D. W. Fraser et al., J. Med.297, 1189 (1977).","journal-title":"J. Med."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1128\/CMR.15.3.506-526.2002","volume":"15","year":"2002","unstructured":"B. S. Fields, R. F. Benson, R. E. Besser, Clin. Microbiol. Rev.15, 506 (2002).","journal-title":"Clin. Microbiol. Rev."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03626.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.3714-3723.2003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067025"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1073\/pnas.0304916101","volume":"101","year":"2004","unstructured":"Z.-Q. Luo, R. R. Isberg, Proc. Natl. Acad. Sci. U.S.A.101, 841 (2004).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094226"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1046\/j.1462-5822.2003.00285.x","volume":"5","year":"2003","unstructured":"H. Nagai, C. R. Roy, Cell. Microbiol.5, 373 (2003).","journal-title":"Cell. Microbiol."},{"key":"e_1_3_2_10_2","unstructured":"Supporting materials are available on Science Online."},{"key":"e_1_3_2_11_2","unstructured":"Additional details are at http:\/\/legionella.cu-genome.org\/annotation\/annotation.html."},{"key":"e_1_3_2_12_2","unstructured":"K. Suwwan de Felipe S. Pampou S. Kalachikov H. A. Shuman unpublished data."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1073\/pnas.95.4.1669","volume":"95","year":"1998","unstructured":"G. Segal, M. Purcell, H. A. Shuman, Proc. Natl. Acad. Sci. U.S.A.95, 1669 (1998).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5352.873"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1046\/j.1365-2958.1999.01642.x","volume":"34","year":"1999","unstructured":"G. Segal, J. J. Russo, H. A. Shuman, Mol. Microbiol.34, 799 (1999).","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1128\/JB.185.15.4630-4637.2003","volume":"185","year":"2003","unstructured":"A. K. Brassinga et al., J. Bacteriol.185, 4630 (2003).","journal-title":"J. Bacteriol."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.192.9.1261","volume":"192","year":"2000","unstructured":"S. Sturgill-Koszycki, M. S. Swanson, J. Exp. Med.192, 1261 (2000).","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1099\/00221287-146-6-1345","volume":"146","year":"2000","unstructured":"S. L. Cirillo, J. Lum, J. D. Cirillo, Microbiology146, 1345 (2000).","journal-title":"Microbiology"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0931379100"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1006\/eesa.2000.1944","volume":"47","year":"2000","unstructured":"G. Fernandez-Leborans, Y. Olalla Herrero, Ecotoxicol. Environ. Saf.47, 266 (2000).","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1046\/j.1365-2958.1999.01430.x","volume":"32","year":"1999","unstructured":"D. De Biase, A. Tramonti, F. Bossa, P. Visca, Mol. Microbiol.32, 1198 (1999).","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1128\/jcm.11.3.286-291.1980","volume":"11","year":"1980","unstructured":"J. R. George, L. Pine, M. W. Reeves, W. Knox Harrell, J. Clin. Microbiol.11, 286 (1980).","journal-title":"J. Clin. Microbiol."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093027"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1462-2920.2000.00076.x","volume":"2","year":"2000","unstructured":"L. Y. Gao, Y. Abu Kwaik, Environ. Microbiol.2, 79 (2000).","journal-title":"Environ. Microbiol."},{"key":"e_1_3_2_25_2","unstructured":"We thank M. Horwitz (UCLA School of Medicine Los Angeles CA) for supplying the Philadelphia 1 bacterial stock used in this study. We are especially grateful to I. S. Edelman for his constant encouragement during the course of this project. Large-scale analyses were aided by the availability of software and hardware from the Bioinformatics Core Facility sponsored by the AMDeC Foundation Inc. This work was supported by NIH grants U01 1 AI 4437 (J.J.R.) and AI 23549 (H.A.S.) a Packard Fellowship for Science and Engineering (J.J.) and funds generously provided by the Columbia Genome Center. S.M.G. is supported by a grant from the Pasteur Foundation of New York."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1099776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:16:11Z","timestamp":1704852971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1099776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,24]]},"references-count":24,"journal-issue":{"issue":"5692","published-print":{"date-parts":[[2004,9,24]]}},"alternative-id":["10.1126\/science.1099776"],"URL":"https:\/\/doi.org\/10.1126\/science.1099776","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,24]]}}}