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These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.<\/jats:p>","DOI":"10.1126\/science.1100021","type":"journal-article","created":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T15:53:01Z","timestamp":1098978781000},"page":"882-884","source":"Crossref","is-referenced-by-count":269,"title":["Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory"],"prefix":"10.1126","volume":"306","author":[{"given":"S. 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Ciavarella T. Sadlon and S. Johnson for their technical expertise. The cognitive and electrophysiological studies were supported by PHS MERIT Award AG06036 PHS P50 MH068789 and a grant from the Stanley Foundation to A.F.T.A. The biochemical data were supported by grants from the NIMH Intramural Program Stanley Medical Research Institute and National Alliance for Research on Schizophrenia and Depression to H.K.M. A.F.T.A. has received an honorarium and research contract funds (July 2004) from Marinus Pharmaceuticals which has licensed the use of chelerythrine for treatment of cognitive function from Yale University."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1100021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T23:23:49Z","timestamp":1704842629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1100021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,29]]},"references-count":20,"journal-issue":{"issue":"5697","published-print":{"date-parts":[[2004,10,29]]}},"alternative-id":["10.1126\/science.1100021"],"URL":"https:\/\/doi.org\/10.1126\/science.1100021","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1022482.256627","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,29]]}}}