{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:54:08Z","timestamp":1792148048819,"version":"4.4.0"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5684","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2004,7,30]]},"abstract":"<jats:p>\n            <jats:italic>Propionibacterium acnes<\/jats:italic>\n            is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other\n            <jats:italic>P. acnes<\/jats:italic>\n            \u2013associated diseases.\n          <\/jats:p>","DOI":"10.1126\/science.1100330","type":"journal-article","created":{"date-parts":[[2004,7,31]],"date-time":"2004-07-31T00:54:41Z","timestamp":1091235281000},"page":"671-673","source":"Crossref","is-referenced-by-count":396,"title":["The Complete Genome Sequence of\n            <i>Propionibacterium Acnes<\/i>\n            , a Commensal of Human Skin"],"prefix":"10.1126","volume":"305","author":[{"given":"Holger","family":"Bru\u0308ggemann","sequence":"first","affiliation":[{"name":"Go\u0308ttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Go\u0308ttingen, Grisebachstra\u00dfe 8, 37077 Go\u0308ttingen, Germany."},{"name":"Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Henne","sequence":"additional","affiliation":[{"name":"Go\u0308ttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Go\u0308ttingen, Grisebachstra\u00dfe 8, 37077 Go\u0308ttingen, Germany."},{"name":"Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hoster","sequence":"additional","affiliation":[{"name":"Go\u0308ttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Go\u0308ttingen, Grisebachstra\u00dfe 8, 37077 Go\u0308ttingen, Germany."},{"name":"Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Liesegang","sequence":"additional","affiliation":[{"name":"Go\u0308ttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Go\u0308ttingen, Grisebachstra\u00dfe 8, 37077 Go\u0308ttingen, Germany."},{"name":"Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnim","family":"Wiezer","sequence":"additional","affiliation":[{"name":"Go\u0308ttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Go\u0308ttingen, Grisebachstra\u00dfe 8, 37077 Go\u0308ttingen, Germany."},{"name":"Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Strittmatter","sequence":"additional","affiliation":[{"name":"Go\u0308ttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Go\u0308ttingen, Grisebachstra\u00dfe 8, 37077 Go\u0308ttingen, Germany."},{"name":"Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hujer","sequence":"additional","affiliation":[{"name":"Go\u0308ttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Go\u0308ttingen, Grisebachstra\u00dfe 8, 37077 Go\u0308ttingen, Germany."},{"name":"Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Du\u0308rre","sequence":"additional","affiliation":[{"name":"Go\u0308ttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Go\u0308ttingen, Grisebachstra\u00dfe 8, 37077 Go\u0308ttingen, Germany."},{"name":"Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Go\u0308ttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Go\u0308ttingen, Grisebachstra\u00dfe 8, 37077 Go\u0308ttingen, Germany."},{"name":"Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000017870","volume":"196","year":"1998","unstructured":"K. T. Hollandet al., Dermatology196, 67 (1998).","journal-title":"Dermatology"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1099\/00221287-143-5-1745","volume":"143","year":"1997","unstructured":"J. E. Miskin, A. M. Farrell, W. J. Cunliffe, K. T. Holland, Microbiology143, 1745 (1997).","journal-title":"Microbiology"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00001432-199906000-00006","volume":"12","year":"1999","unstructured":"E. Ingham, Curr. Opin. Infect. Dis.12, 191 (1999).","journal-title":"Curr. Opin. Infect. Dis."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000068476","volume":"206","year":"2003","unstructured":"A. Koreck, A. Pivarcsi, A. Dobozy, L. Kemeny, Dermatology206, 96 (2003).","journal-title":"Dermatology"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1046\/j.1365-2133.2002.04602.x","volume":"146","year":"2002","unstructured":"U. Jappe, E. Ingham, J. Henwood, K. T. Holland, Br. J. Dermatol.146, 202 (2002).","journal-title":"Br. J. Dermatol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1574-6968.2000.tb09337.x","volume":"191","year":"2000","unstructured":"M. D. Farrar, E. Ingham, K. T. Holland, FEMS Microbiol. Lett.191, 183 (2000).","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_8_2","first-page":"477","volume":"69","year":"1996","unstructured":"E. Jakabet al., Yale J. Biol. Med.69, 477 (1996).","journal-title":"Yale J. Biol. Med."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/path.1243","volume":"198","year":"2002","unstructured":"T. Yamadaet al., J. Pathol.198, 541 (2002).","journal-title":"J. Pathol."},{"key":"e_1_3_2_10_2","unstructured":"The sequence reported in this paper has been deposited in GenBank with accession no. AE017283."},{"key":"e_1_3_2_11_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_2_12_2","unstructured":"S. Hujer P. D\u00fcrre unpublished data."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1099\/00221287-139-8-1745","volume":"139","year":"1993","unstructured":"E. M. Gribbon, W. J. Cunliffe, K. T. Holland, J. Gen. Microbiol.139, 1745 (1993).","journal-title":"J. Gen. Microbiol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1139\/m97-044","volume":"43","year":"1997","unstructured":"B. Steiner, S. Romero-Steiner, D. Cruce, R. George, Can. J. Microbiol.43, 315 (1997).","journal-title":"Can. J. Microbiol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1099\/mic.0.26942-0","volume":"150","year":"2004","unstructured":"G. Makris, J. D. Wright, E. Ingham, K. T. Holland, Microbiology150, 2005 (2004).","journal-title":"Microbiology"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"38167","DOI":"10.1074\/jbc.M303544200","volume":"278","year":"2003","unstructured":"S. Lang, M. Palmer, J. Biol. Chem.278, 38167 (2003).","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.micpath.2003.09.002","volume":"36","year":"2004","unstructured":"Z. Csukas, B. Banizs, F. Rozgonyi, Microb. Pathog.36, 171 (2004).","journal-title":"Microb. Pathog."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1128\/IAI.72.5.2710-2722.2004","volume":"72","year":"2004","unstructured":"D. Comfort, R. T. Clubb, Infect. Immun.72, 2710 (2004).","journal-title":"Infect. Immun."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1128\/jb.177.9.2475-2480.1995","volume":"177","year":"1995","unstructured":"A. van der Endeet al., J. Bacteriol.177, 2475 (1995).","journal-title":"J. Bacteriol."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1128\/IAI.69.6.4185-4191.2001","volume":"69","year":"2001","unstructured":"K. K. Singh, X. Zhang, A. S. Patibandla, P. Chien, S. Laal, Infect. Immun.69, 4185 (2001).","journal-title":"Infect. Immun."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1128\/iai.61.4.1509-1515.1993","volume":"61","year":"1993","unstructured":"R. J. Boothet al., Infect. Immun.61, 1509 (1993).","journal-title":"Infect. Immun."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1128\/iai.63.3.954-960.1995","volume":"63","year":"1995","unstructured":"P. W. Hermanset al., Infect. Immun.63, 954 (1995).","journal-title":"Infect. Immun."},{"key":"e_1_3_2_23_2","unstructured":"This project was carried out within the framework of the Competence Network G\u00f6ttingen \u201cGenome Research on Bacteria\u201d (GenoMik) financed by the German Federal Ministry of Education and Research (BMBF). A supporting grant was provided by the Nieders\u00e4chisches Ministerium f\u00fcr Wissenschaft und Kultur to the G\u00f6ttingen Genomics Laboratory. H.B. is holder of a fellowship of the German Academy of Natural Scientists Leopoldina funded by the BMBF."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1100330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T01:51:59Z","timestamp":1704851519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1100330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,30]]},"references-count":22,"journal-issue":{"issue":"5684","published-print":{"date-parts":[[2004,7,30]]}},"alternative-id":["10.1126\/science.1100330"],"URL":"https:\/\/doi.org\/10.1126\/science.1100330","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,30]]}}}