{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:22:05Z","timestamp":1790868125095,"version":"4.1.0"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5706","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,1,7]]},"abstract":"<jats:p>\n                    <jats:italic>Dehalococcoides ethenogenes<\/jats:italic>\n                    is the only bacterium known to reductively dechlorinate the groundwater pollutants, tetrachloroethene (PCE) and trichloroethene, to ethene. Its 1,469,720\u00e2\u0080\u0093base pair chromosome contains large dynamic duplicated regions and integrated elements. Genes encoding 17 putative reductive dehalogenases, nearly all of which were adjacent to genes for transcription regulators, and five hydrogenase complexes were identified. These findings, plus a limited repertoire of other metabolic modes, indicate that\n                    <jats:italic>D. ethenogenes<\/jats:italic>\n                    is highly evolved to utilize halogenated organic compounds and H\n                    <jats:sub>2<\/jats:sub>\n                    . Diversification of reductive dehalogenase functions appears to have been mediated by recent genetic exchange and amplification. Genome analysis provides insights into the organism's complex nutrient requirements and suggests that an ancestor was a nitrogen-fixing autotroph.\n                  <\/jats:p>","DOI":"10.1126\/science.1102226","type":"journal-article","created":{"date-parts":[[2005,1,6]],"date-time":"2005-01-06T19:15:04Z","timestamp":1105038904000},"page":"105-108","source":"Crossref","is-referenced-by-count":388,"title":["Genome Sequence of the PCE-Dechlorinating Bacterium\n                    <i>Dehalococcoides ethenogenes<\/i>"],"prefix":"10.1126","volume":"307","author":[{"given":"Rekha","family":"Seshadri","sequence":"first","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"Fachgebiet Technische Biochemie, Institut fu\u00cc\u0088r Biotechnologie, Technische Universita\u00cc\u0088t Berlin, Seestrasse 13, D-13353 Berlin, Germany."},{"name":"Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218, USA."},{"name":"Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA."},{"name":"Departments of Pharmacology and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street N.W., Washington, DC 20037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Adrian","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"Fachgebiet Technische Biochemie, Institut fu\u00cc\u0088r Biotechnologie, Technische Universita\u00cc\u0088t Berlin, Seestrasse 13, D-13353 Berlin, Germany."},{"name":"Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218, USA."},{"name":"Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA."},{"name":"Departments of Pharmacology and Microbiology and Tropical Medicine, George Washington 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