{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:21:09Z","timestamp":1791512469607,"version":"4.3.4"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5700","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2004,11,19]]},"abstract":"<jats:p>\n                    The human polyomavirus, JCV, causes the fatal demyelinating disease progressive multifocal leukoencephalopathy in immunocompromised patients. We found that the serotonergic receptor 5HT\n                    <jats:sub>2A<\/jats:sub>\n                    R could act as the cellular receptor for JCV on human glial cells. The 5HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptor antagonists inhibited JCV infection, and monoclonal antibodies directed at 5HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptors blocked infection of glial cells by JCV, but not by SV40. Transfection of 5HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptor\u2013negative HeLa cells with a 5HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptor rescued virus infection, and this infection was blocked by antibody to the 5HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptor. A tagged 5HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptor colocalized with labeled JCV in an endosomal compartment following internalization. Serotonin receptor antagonists may thus be useful in the treatment of progressive multifocal leukoencephalopathy.\n                  <\/jats:p>","DOI":"10.1126\/science.1103492","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T16:33:51Z","timestamp":1100795631000},"page":"1380-1383","source":"Crossref","is-referenced-by-count":390,"title":["The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells"],"prefix":"10.1126","volume":"306","author":[{"given":"Gwendolyn F.","family":"Elphick","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Pathobiology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, USA."},{"name":"Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Querbes","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Pathobiology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, USA."},{"name":"Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joslynn A.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Pathobiology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, USA."},{"name":"Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen V.","family":"Gee","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Pathobiology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, USA."},{"name":"Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Eash","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Pathobiology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, USA."},{"name":"Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Manley","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Pathobiology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, USA."},{"name":"Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling","family":"Dugan","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Pathobiology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, USA."},{"name":"Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Stanifer","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Pathobiology, Brown University, Providence, RI 02912, USA."},{"name":"Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown 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We thank J. Sedivy for critical discussions during the preparation of the manuscript. We also thank L. Brossay for the pMSCV plasmid R. Creton for critical help with confocal microscopy and A. Robinson A. Bozek and L. St. Pierre for administrative assistance. Work in our laboratory was supported by a grant from the National Cancer Institute R01 CA71878 and by a grant from the National Institute of Neurological Disorders and Stroke R01 NS43097. W.Q. is supported by a Graduate Assistantship in Areas of National Need training grant from the Department of Education P200A030100. Work in the Roth lab was supported by RO1MH57635 RO1MH61887 and the National Institute of Mental Health Psychoactive Drug Screening Program to B.L.R."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1103492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T23:44:52Z","timestamp":1704843892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1103492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,19]]},"references-count":40,"journal-issue":{"issue":"5700","published-print":{"date-parts":[[2004,11,19]]}},"alternative-id":["10.1126\/science.1103492"],"URL":"https:\/\/doi.org\/10.1126\/science.1103492","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1022508.255682","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1022508.264777","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,19]]}}}