{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:09:50Z","timestamp":1791281390550,"version":"4.1.0"},"reference-count":23,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5707","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,1,14]]},"abstract":"<jats:p>\n                    Genetic studies have elucidated mechanisms that regulate aging, but there has been little progress in identifying drugs that delay aging. Here, we report that ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    and delay age-related declines of physiological processes, indicating that these compounds retard the aging process. These compounds, two of which are approved for human use, are anticonvulsants that modulate neural activity. These compounds also regulated neuromuscular activity in nematodes. These findings suggest that the life-span\u2013extending activity of these compounds is related to the anticonvulsant activity and implicate neural activity in the regulation of aging.\n                  <\/jats:p>","DOI":"10.1126\/science.1105299","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T16:48:22Z","timestamp":1105634902000},"page":"258-262","source":"Crossref","is-referenced-by-count":166,"title":["Anticonvulsant Medications Extend Worm Life-Span"],"prefix":"10.1126","volume":"307","author":[{"given":"Kimberley","family":"Evason","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idella","family":"Yamben","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas F.","family":"Covey","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Kornfeld","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35041700"},{"key":"e_1_3_1_3_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_1_4_2","unstructured":"S. Hughes K. Evason data not shown."},{"key":"e_1_3_1_5_2","unstructured":"B. G. Katzung Ed. Basic and Clinical Pharmacology (Appleton and Lange Upper Saddle River NJ ed. 7 1998)."},{"key":"e_1_3_1_6_2","unstructured":"R. H. Levy R. H. Mattson B. S. Meldrum E. Perucca Eds. Antiepileptic drugs (Lippincott Williams and Wilkins Philadelphia ed. 5 2002)."},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9600196"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400848101"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/154.4.1597"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080147"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.166.1.161"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13091"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/366461a0"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1474-9728.2002.00003.x"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/45544"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7394"},{"key":"e_1_3_1_17_2","unstructured":"D. L. Riddle Ed. C. elegans II Cold Spring Harbor Monogr. Ser. 33 (Cold Spring Harbor Laboratory Press Plainview NY 1997)."},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/104.4.619"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.22.12593"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80847-8"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250610"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.60.5.1121"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-13-04842.1998"},{"key":"e_1_3_1_24_2","unstructured":"Strains were provided by the Caenorhabditis Genetics Center which is funded by the NIH National Center for Research Resources. We thank M. Nonet for helpful suggestions and aex-3 mutants S. Hughes for experimental assistance and D. Redmond for assistance with graphics. Support was provided by the Washington University Alzheimer's Disease Research Center (grant no. P50 AG05681) and the Longer Life Foundation a Reinsurance Group of America Inc. (RGA)\/Washington University Partnership (grant no. 1999-001). C.H. was supported by a Predoctoral Fellowship from the Howard Hughes Medical Institute. K.K. is a scholar of the Leukemia and Lymphoma Society."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1105299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T20:59:08Z","timestamp":1704833948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1105299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,14]]},"references-count":23,"journal-issue":{"issue":"5707","published-print":{"date-parts":[[2005,1,14]]}},"alternative-id":["10.1126\/science.1105299"],"URL":"https:\/\/doi.org\/10.1126\/science.1105299","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1023419.269739","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1023419.280695","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1023419.793516976","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,14]]}}}