{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:26:35Z","timestamp":1791026795224,"version":"4.1.0"},"reference-count":19,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5716","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,3,18]]},"abstract":"<jats:p>Type VII collagen defects cause recessive dystrophic epidermolysis bullosa (RDEB), a blistering skin disorder often accompanied by epidermal cancers. To study the role of collagen VII in these cancers, we examined Ras-driven tumorigenesis in RDEB keratinocytes. Cells devoid of collagen VII did not form tumors in mice, whereas those retaining a specific collagen VII fragment (the amino-terminal noncollagenous domain NC1) were tumorigenic. Forced NC1 expression restored tumorigenicity to collagen VII\u2013null epidermis in a non\u2013cell-autonomous fashion. Fibronectin-like sequences within NC1 (FNC1) promoted tumor cell invasion in a laminin 5\u2013dependent manner and were required for tumorigenesis. Tumor-stroma interactions mediated by collagen VII thus promote neoplasia, and retention of NC1 sequences in a subset of RDEB patients may contribute to their increased susceptibility to squamous cell carcinoma.<\/jats:p>","DOI":"10.1126\/science.1106209","type":"journal-article","created":{"date-parts":[[2005,3,18]],"date-time":"2005-03-18T04:18:34Z","timestamp":1111119514000},"page":"1773-1776","source":"Crossref","is-referenced-by-count":114,"title":["Type VII Collagen Is Required for Ras-Driven Human Epidermal Tumorigenesis"],"prefix":"10.1126","volume":"307","author":[{"given":"Susana","family":"Ortiz-Urda","sequence":"first","affiliation":[{"name":"VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA."},{"name":"Program in Epithelial Biology, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Garcia","sequence":"additional","affiliation":[{"name":"VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA."},{"name":"Program in Epithelial Biology, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Green","sequence":"additional","affiliation":[{"name":"VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA."},{"name":"Program in Epithelial Biology, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA."},{"name":"Program in Epithelial Biology, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Lin","sequence":"additional","affiliation":[{"name":"VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA."},{"name":"Program in Epithelial Biology, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dallas P.","family":"Veitch","sequence":"additional","affiliation":[{"name":"VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA."},{"name":"Program in Epithelial Biology, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn Y.","family":"Sakai","sequence":"additional","affiliation":[{"name":"VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA."},{"name":"Program in Epithelial Biology, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyangkyu","family":"Lee","sequence":"additional","affiliation":[{"name":"VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA."},{"name":"Program in Epithelial Biology, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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We thank A. E. Oro H. Y. Chang D. W. Felsher E. Bauer J. Reuter T. Ridky P. Dumesic Z. Siprashvili and R. Kimmel for presubmission review and helpful discussions; K. Wolff and K. Rappersberger for support; T. Cai for PI3K reagents; L. Nall for help with donor information; N. L. Charbonneau for antibody preparation; and E. Pfendner for mutation detection."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1106209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:21:37Z","timestamp":1704860497000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1106209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,18]]},"references-count":19,"journal-issue":{"issue":"5716","published-print":{"date-parts":[[2005,3,18]]}},"alternative-id":["10.1126\/science.1106209"],"URL":"https:\/\/doi.org\/10.1126\/science.1106209","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,18]]}}}