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Asymmetric somite formation correlates with a left-right desynchronization of the segmentation clock oscillations. These data implicate retinoic acid as an endogenous signal that maintains the bilateral synchrony of mesoderm segmentation, and therefore controls bilateral symmetry, in vertebrate embryos.<\/jats:p>","DOI":"10.1126\/science.1108363","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T13:33:02Z","timestamp":1109338382000},"page":"563-566","source":"Crossref","is-referenced-by-count":210,"title":["Retinoic Acid Controls the Bilateral Symmetry of Somite Formation in the Mouse Embryo"],"prefix":"10.1126","volume":"308","author":[{"given":"Julien","family":"Vermot","sequence":"first","affiliation":[{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire, CNRS\/INSERM\/ULP\/Colle\u0300ge de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France."},{"name":"Departments of Medicine and Molecular Biology, Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jabier Gallego","family":"Llamas","sequence":"additional","affiliation":[{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire, CNRS\/INSERM\/ULP\/Colle\u0300ge de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France."},{"name":"Departments of Medicine and Molecular Biology, Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vale\u0301rie","family":"Fraulob","sequence":"additional","affiliation":[{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire, CNRS\/INSERM\/ULP\/Colle\u0300ge de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France."},{"name":"Departments of Medicine and Molecular Biology, Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Niederreither","sequence":"additional","affiliation":[{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire, CNRS\/INSERM\/ULP\/Colle\u0300ge de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France."},{"name":"Departments of Medicine and Molecular Biology, Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chambon","sequence":"additional","affiliation":[{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire, CNRS\/INSERM\/ULP\/Colle\u0300ge de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France."},{"name":"Departments of Medicine and Molecular Biology, Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Dolle\u0301","sequence":"additional","affiliation":[{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire, CNRS\/INSERM\/ULP\/Colle\u0300ge de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France."},{"name":"Departments of Medicine and Molecular Biology, Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(76)80131-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80451-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00055-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00437-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90574-I"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00565-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(04)00026-7"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.5.8.1333"},{"key":"e_1_3_2_10_2","unstructured":"J. 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Biol., T. 22 (1906).","journal-title":"Arch. Biol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02190"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1084703"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1084403"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80619-4"},{"key":"e_1_3_2_26_2","unstructured":"We thank B. Schuhbaur for technical help J. Rossant for RARE- lacZ mice P. McCaffery for antibody to RALDH2 and K. Storey and O. Pourqui\u00e9 for discussions. Supported by funds from CNRS INSERM Coll\u00e8ge de France Minist\u00e8re de la Recherche and Institut Universitaire de France. J.V. was supported by fellowships from the Association pour la Recherche sur le Cancer and Fondation pour la Recherche M\u00e9dicale."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1108363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T23:34:47Z","timestamp":1704843287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1108363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,22]]},"references-count":25,"journal-issue":{"issue":"5721","published-print":{"date-parts":[[2005,4,22]]}},"alternative-id":["10.1126\/science.1108363"],"URL":"https:\/\/doi.org\/10.1126\/science.1108363","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1024389.287906","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,22]]}}}