{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:07:16Z","timestamp":1792649236295,"version":"4.5.0"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5713","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,2,25]]},"abstract":"<jats:p>\n                    <jats:italic>Shigella<\/jats:italic>\n                    , the leading cause of bacillary dysentery, uses a type III secretion system (TTSS) to inject proteins into human cells, leading to bacterial invasion and a vigorous inflammatory response. The bacterium is protected against the response by the O antigen of lipopolysaccharide (LPS) on its surface. We show that bacteriophage-encoded glucosylation of\n                    <jats:italic>Shigella<\/jats:italic>\n                    O antigen, the basis of different serotypes, shortens the LPS molecule by around half. This enhances TTSS function without compromising the protective properties of the LPS. Thus, LPS glucosylation promotes bacterial invasion and evasion of innate immunity, which may have contributed to the emergence of serotype diversity in\n                    <jats:italic>Shigella<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1126\/science.1108472","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T16:00:33Z","timestamp":1109260833000},"page":"1313-1317","source":"Crossref","is-referenced-by-count":282,"title":["Optimization of Virulence Functions Through Glucosylation of\n                    <i>Shigella<\/i>\n                    LPS"],"prefix":"10.1126","volume":"307","author":[{"given":"Nicholas P.","family":"West","sequence":"first","affiliation":[{"name":"Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Flowers Building, Imperial College London, London SW7 2AZ, UK"},{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Unite\u0301 INSERM 389, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."},{"name":"Plate-Forme de Microscopie Electronique, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."},{"name":"Unite\u0301 de Re\u0301sonance Magne\u0301tique Nucle\u0301aire des Biomole\u0301cules, URA 2185 CNRS; Unite\u0301 INSERM 389, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Sansonetti","sequence":"additional","affiliation":[{"name":"Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Flowers Building, Imperial College London, London SW7 2AZ, UK"},{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Unite\u0301 INSERM 389, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."},{"name":"Plate-Forme de Microscopie Electronique, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."},{"name":"Unite\u0301 de Re\u0301sonance Magne\u0301tique Nucle\u0301aire des Biomole\u0301cules, URA 2185 CNRS; Unite\u0301 INSERM 389, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe\u0308lle","family":"Mounier","sequence":"additional","affiliation":[{"name":"Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Flowers Building, Imperial College London, London SW7 2AZ, UK"},{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Unite\u0301 INSERM 389, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."},{"name":"Plate-Forme de Microscopie Electronique, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."},{"name":"Unite\u0301 de Re\u0301sonance Magne\u0301tique Nucle\u0301aire des Biomole\u0301cules, URA 2185 CNRS; Unite\u0301 INSERM 389, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Exley","sequence":"additional","affiliation":[{"name":"Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Flowers Building, Imperial College London, London SW7 2AZ, UK"},{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Unite\u0301 INSERM 389, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."},{"name":"Plate-Forme de Microscopie Electronique, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."},{"name":"Unite\u0301 de Re\u0301sonance Magne\u0301tique Nucle\u0301aire des Biomole\u0301cules, URA 2185 CNRS; Unite\u0301 INSERM 389, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Parsot","sequence":"additional","affiliation":[{"name":"Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Flowers Building, Imperial College London, London SW7 2AZ, UK"},{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Unite\u0301 INSERM 389, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."},{"name":"Plate-Forme de Microscopie Electronique, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Ce\u0301dex 15, France."},{"name":"Unite\u0301 de Re\u0301sonance Magne\u0301tique Nucle\u0301aire des Biomole\u0301cules, URA 2185 CNRS; 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