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Here, we show that an increase in the rate of epithelial cell turnover in the large intestine acts like an \u201cepithelial escalator\u201d to expel\n                    <jats:italic>Trichuris<\/jats:italic>\n                    and that the rate of epithelial cell movement is under immune control by the cytokine interleukin-13 and the chemokine CXCL10. This host protective mechanism against intestinal pathogens has implications for our wider understanding of the multifunctional role played by intestinal epithelium in mucosal defense.\n                  <\/jats:p>","DOI":"10.1126\/science.1108661","type":"journal-article","created":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T17:03:26Z","timestamp":1117731806000},"page":"1463-1465","source":"Crossref","is-referenced-by-count":356,"title":["Accelerated Intestinal Epithelial Cell Turnover: A New Mechanism of Parasite Expulsion"],"prefix":"10.1126","volume":"308","author":[{"given":"Laura J.","family":"Cliffe","sequence":"first","affiliation":[{"name":"Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK."},{"name":"Department of Molecular Biology and Biochemistry, University of California Irvine, 3205 McGaugh Hall, Irvine, CA 92697, USA."},{"name":"Epistem Limited, Incubator Building, Grafton Street, Manchester, M13 9XX, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil E","family":"Humphreys","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK."},{"name":"Department of Molecular Biology and Biochemistry, University of California Irvine, 3205 McGaugh Hall, Irvine, CA 92697, USA."},{"name":"Epistem Limited, Incubator Building, Grafton Street, Manchester, M13 9XX, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Lane","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK."},{"name":"Department of Molecular Biology and Biochemistry, University of California Irvine, 3205 McGaugh Hall, Irvine, CA 92697, USA."},{"name":"Epistem Limited, Incubator Building, Grafton Street, Manchester, M13 9XX, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris S.","family":"Potten","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK."},{"name":"Department of Molecular Biology and Biochemistry, University of California Irvine, 3205 McGaugh Hall, Irvine, CA 92697, USA."},{"name":"Epistem Limited, Incubator Building, Grafton Street, Manchester, M13 9XX, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cath","family":"Booth","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK."},{"name":"Department of Molecular Biology and Biochemistry, University of California Irvine, 3205 McGaugh Hall, Irvine, CA 92697, USA."},{"name":"Epistem Limited, Incubator Building, Grafton Street, Manchester, M13 9XX, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Grencis","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK."},{"name":"Department of Molecular Biology and Biochemistry, University of California Irvine, 3205 McGaugh Hall, Irvine, CA 92697, USA."},{"name":"Epistem Limited, Incubator Building, Grafton Street, Manchester, M13 9XX, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","unstructured":"A. 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