{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:45:11Z","timestamp":1792727111154,"version":"4.5.0"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5724","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,5,13]]},"abstract":"<jats:p>\n                    In plants, systemic acquired resistance (SAR) is established as a result of NPR1-regulated expression of pathogenesis-related (\n                    <jats:italic>PR<\/jats:italic>\n                    ) genes. Using gene expression profiling in\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    , we found that in addition to controlling the expression of\n                    <jats:italic>PR<\/jats:italic>\n                    genes, NPR1 also directly controls the expression of the protein secretory pathway genes. Up-regulation of these genes is essential for SAR, because mutations in some of them diminished the secretion of PR proteins (for example, PR1), resulting in reduced resistance. We provide evidence that NPR1 coordinately regulates these secretion-related genes through a previously undescribed cis-element. Activation of this cis-element is controlled by a transcription factor that is translocated into the nucleus upon SAR induction.\n                  <\/jats:p>","DOI":"10.1126\/science.1108791","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T17:03:05Z","timestamp":1115917385000},"page":"1036-1040","source":"Crossref","is-referenced-by-count":485,"title":["Induction of Protein Secretory Pathway Is Required for Systemic Acquired Resistance"],"prefix":"10.1126","volume":"308","author":[{"given":"Dong","family":"Wang","sequence":"first","affiliation":[{"name":"Developmental, Cell and Molecular Biology Group, Department of Biology, Post Office Box 91000, Duke University, Durham, NC 27708, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie D.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Developmental, Cell and Molecular Biology Group, Department of Biology, Post Office Box 91000, Duke University, Durham, NC 27708, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenu","family":"Kesarwani","sequence":"additional","affiliation":[{"name":"Developmental, Cell and Molecular Biology Group, Department of Biology, Post Office Box 91000, Duke University, Durham, NC 27708, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinnian","family":"Dong","sequence":"additional","affiliation":[{"name":"Developmental, Cell and Molecular Biology Group, Department of Biology, Post Office Box 91000, Duke University, Durham, NC 27708, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.phyto.42.040803.140421"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2004.07.005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/82521"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.2003.01717.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.007591"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/pmpp.1999.0213"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.12.12.2339"},{"key":"e_1_3_2_9_2","first-page":"615","volume":"11","year":"1999","unstructured":"A. Vitale, J. Denecke, Plant Cell11, 615 (1999).","journal-title":"Plant Cell"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.19.110701.153949"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.6.3984"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-5564(01)00107-9"},{"key":"e_1_3_2_13_2","unstructured":"http:\/\/genome-www5.stanford.edu"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00023606"},{"key":"e_1_3_2_15_2","first-page":"391","volume":"7","year":"1995","unstructured":"J. Denecke et al., Plant Cell7, 391 (1995).","journal-title":"Plant Cell"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.102.012633"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.11.10.1935"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00213-0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086391"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1379\/1466-1268(2001)006<0201:GAOTHS>2.0.CO;2"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(03)00559-6"},{"key":"e_1_3_2_22_2","unstructured":"D. Wang N. D. Weaver M. Kesarwani X. Dong data not shown."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00219-2"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.007609"},{"key":"e_1_3_2_25_2","first-page":"28","volume":"2","year":"1994","unstructured":"T. L. Bailey, C. Elkan, Proc. Int. Conf. Intell. Syst. Mol. Biol.2, 28 (1994).","journal-title":"Proc. Int. Conf. Intell. Syst. Mol. Biol."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.014894"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00024-4"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.2307\/3869945"},{"key":"e_1_3_2_29_2","unstructured":"We thank P. Benfey W. Durrant J. Siedow T. P. Sun D. Thiele and L. Tyler for critical readings of the manuscript and helpful discussion and X. Li for providing the tga2 tga5 tga6 triple mutant. This project is supported by a NSF 2010 grant and a grant from the U.S. Department of Agriculture."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1108791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T23:11:11Z","timestamp":1704841871000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1108791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,13]]},"references-count":28,"journal-issue":{"issue":"5724","published-print":{"date-parts":[[2005,5,13]]}},"alternative-id":["10.1126\/science.1108791"],"URL":"https:\/\/doi.org\/10.1126\/science.1108791","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1025895.319842","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1025895.322847","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1025895.323905","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,13]]}}}