{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:06:03Z","timestamp":1791327963601,"version":"4.3.1"},"reference-count":24,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5725","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,5,20]]},"abstract":"<jats:p>\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    causes a variety of diseases, including gastroenteritis and typhoid fever. The success of this pathogen depends on its capacity to proliferate within host cells in a membrane-bound compartment. We found that the\n                    <jats:italic>Salmonella<\/jats:italic>\n                    -containing vacuole recruited the plus-end\u2013directed motor kinesin. Bacterial effector proteins translocated into the host cell by a type III secretion system antagonistically regulated this event. Among these effectors, SifA targeted SKIP, a host protein that down-regulated the recruitment of kinesin on the bacterial vacuole and, in turn, controlled vacuolar membrane dynamics.\n                  <\/jats:p>","DOI":"10.1126\/science.1110225","type":"journal-article","created":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T17:08:19Z","timestamp":1116522499000},"page":"1174-1178","source":"Crossref","is-referenced-by-count":222,"title":["The Intracellular Fate of\n                    <i>Salmonella<\/i>\n                    Depends on the Recruitment of Kinesin"],"prefix":"10.1126","volume":"308","author":[{"given":"Emmanuel","family":"Boucrot","sequence":"first","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Universite\u0301 de la Me\u0301diterrane\u0301e, Parc Scientifique de Luminy, Case 906-13288 Marseille Cedex 9, France."},{"name":"Molecular Pharmacology, UMR 599 INSERM, and Institut Paoli-Calmettes, 27 Boulevard Lei\u0308 Roure, 13009 Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Henry","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Universite\u0301 de la Me\u0301diterrane\u0301e, Parc Scientifique de Luminy, Case 906-13288 Marseille Cedex 9, France."},{"name":"Molecular Pharmacology, UMR 599 INSERM, and Institut Paoli-Calmettes, 27 Boulevard Lei\u0308 Roure, 13009 Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Borg","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Universite\u0301 de la Me\u0301diterrane\u0301e, Parc Scientifique de Luminy, Case 906-13288 Marseille Cedex 9, France."},{"name":"Molecular Pharmacology, UMR 599 INSERM, and Institut Paoli-Calmettes, 27 Boulevard Lei\u0308 Roure, 13009 Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Gorvel","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Universite\u0301 de la Me\u0301diterrane\u0301e, Parc Scientifique de Luminy, Case 906-13288 Marseille Cedex 9, France."},{"name":"Molecular Pharmacology, UMR 599 INSERM, and Institut Paoli-Calmettes, 27 Boulevard Lei\u0308 Roure, 13009 Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ste\u0301phane","family":"Me\u0301resse","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Universite\u0301 de la Me\u0301diterrane\u0301e, Parc Scientifique de Luminy, Case 906-13288 Marseille Cedex 9, France."},{"name":"Molecular Pharmacology, UMR 599 INSERM, and Institut Paoli-Calmettes, 27 Boulevard Lei\u0308 Roure, 13009 Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7618105"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7539"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2002.30604.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.22.10544"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1996.tb02497.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.13.3235"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-9-2705"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207901200"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/5.6.355"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)01730-8"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.27.1.503"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg517"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00949"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-08-0614"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1101-992"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.15.1.141"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)01102-8"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1002-e236"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.2.469"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.4.1021"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(01)02184-5"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-07-0553"},{"key":"e_1_3_1_24_2","unstructured":"Values represent the means \u00b1 SD of three independent experiments n >100 events for each experiment."},{"key":"e_1_3_1_25_2","unstructured":"We thank D. Holden for bacterial strains R. Vale for the anti-kinesin HC (PCP42) M. Way for the pGFP-KLC2-TPR V. Ollendorf for the pBTM 116 and pBTM 116 -lamin vectors and the Kazusa DNA Research Institut for the cDNA encoding full-length KIAA 0842. We are grateful to J. Deiwick A. Dumont and C.-L. Ku for DNA constructs and to C. de Chastellier J. Ewbank S. Garvis N. Lapaque and S. Salcedo for critical review of this manuscript. E.B. and T.H. were recipients of fellowships from the French Ministry of Research Association pour la Recherche sur le Cancer and Fondation pour la Recherche M\u00e9dicale. This work was supported by institutional grants from CNRS and INSERM and the Microban EU network grant MRTN-CT-2003-504227."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1110225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T22:55:06Z","timestamp":1704840906000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1110225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,20]]},"references-count":24,"journal-issue":{"issue":"5725","published-print":{"date-parts":[[2005,5,20]]}},"alternative-id":["10.1126\/science.1110225"],"URL":"https:\/\/doi.org\/10.1126\/science.1110225","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1026086.323941","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1026086.323052","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,20]]}}}