{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:45:03Z","timestamp":1792730703236,"version":"4.5.0"},"reference-count":19,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5737","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,8,12]]},"abstract":"<jats:p>\n                    Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived\n                    <jats:italic>Drosophila<\/jats:italic>\n                    insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can modify stem cell activity in a niche-independent manner. We also reveal a crucial direct role of DILPs in controlling germline cyst growth and vitellogenesis.\n                  <\/jats:p>","DOI":"10.1126\/science.1111410","type":"journal-article","created":{"date-parts":[[2005,8,11]],"date-time":"2005-08-11T22:24:18Z","timestamp":1123799058000},"page":"1071-1073","source":"Crossref","is-referenced-by-count":311,"title":["Direct Control of Germline Stem Cell Division and Cyst Growth by Neural Insulin in\n                    <i>Drosophila<\/i>"],"prefix":"10.1126","volume":"309","author":[{"given":"Leesa","family":"LaFever","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4120B Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232\u20138240, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Drummond-Barbosa","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4120B Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232\u20138240, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1997.062.01.006"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/35102160"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81424-5"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.0135"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004410100367"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)01043-6"},{"key":"e_1_3_1_8_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_1_9_2","unstructured":"L. LaFever D. Drummond-Barbosa unpublished data."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070058"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00068-9"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.3.8603594"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1057987"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00932"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5487.2122"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/026010609300900106"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(01)00548-3"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.2003.7107001.x"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.117.4.1223"},{"key":"e_1_3_1_20_2","unstructured":"We thank E. Hafen E. Rulifson and the Bloomington Stock Center for fly stocks and D. Greenstein L. Lee B. Appel and R. Cox for valuable comments on this manuscript. Supported by Development Funds from the Vanderbilt University School of Medicine by American Cancer Society grant no. IRG-58-009-47 and by National Institutes of Health grant no. GM 069875."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1111410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:45:51Z","timestamp":1704836751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1111410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,12]]},"references-count":19,"journal-issue":{"issue":"5737","published-print":{"date-parts":[[2005,8,12]]}},"alternative-id":["10.1126\/science.1111410"],"URL":"https:\/\/doi.org\/10.1126\/science.1111410","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,12]]}}}