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Recent studies suggest that mechanisms underlying these pains and sensitivity to estrogen involve the growth into the ectopic endometrial tissue of a nerve supply, which could have a varied and widespread influence on the activity of neurons throughout the central nervous system.<\/jats:p>","DOI":"10.1126\/science.1111445","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T17:33:36Z","timestamp":1118338416000},"page":"1587-1589","source":"Crossref","is-referenced-by-count":381,"title":["The Pains of Endometriosis"],"prefix":"10.1126","volume":"308","author":[{"given":"Karen J.","family":"Berkley","sequence":"first","affiliation":[{"name":"Program in Neuroscience, Department of Psychology, Florida State University, Tallahassee, FL 32306, USA."},{"name":"Department of Obstetrics and Gynecology, Center for the Health Sciences, David Geffen School of Medicine at UCLA, Room 27-117, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA."},{"name":"Department of Neurobiology, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Post Office Box 95, Rootstown, OH 44272, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"Rapkin","sequence":"additional","affiliation":[{"name":"Program in Neuroscience, Department of Psychology, Florida State University, Tallahassee, FL 32306, USA."},{"name":"Department of Obstetrics and Gynecology, Center for the Health Sciences, David Geffen School of Medicine at UCLA, Room 27-117, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA."},{"name":"Department of Neurobiology, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Post Office Box 95, Rootstown, OH 44272, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond E.","family":"Papka","sequence":"additional","affiliation":[{"name":"Program in Neuroscience, Department of Psychology, Florida State University, Tallahassee, FL 32306, USA."},{"name":"Department of Obstetrics and Gynecology, Center for the Health Sciences, David Geffen School of Medicine at UCLA, Room 27-117, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA."},{"name":"Department of Neurobiology, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Post Office Box 95, Rootstown, OH 44272, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17403-5"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80332-X"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.10.2715"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01753-0"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00024677-200403020-00003"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57554-2"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.12.2668"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg275"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg152"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.7.1895"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(05)60556-7"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02792.x"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00405-5"},{"key":"e_1_3_1_15_2","unstructured":"K. J. Berkley Physiol. Behav. in press."},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403663101"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.11.001"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-5900(03)00720-X"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(03)31003-4"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.66.032802.154945"},{"key":"e_1_3_1_21_2","first-page":"251","year":"2002","unstructured":"R. J. Rapkin, J. Jolin, in Pain Management: A Practical Guide for Clinicians, R. S. Weiner, Ed. (CRC Press, Boca Raton, FL, ed. 6, 2002), pp. 251\u2013268.","journal-title":"Pain Management: A Practical Guide for Clinicians"},{"key":"e_1_3_1_22_2","unstructured":"We thank J. Chalcraft for assistance with Fig. 1. Supported by NIH grants R01 NS11892 R21 DK063937 and RO1 NS22526. A.J.R. has received honoraria from TAP the manufacturer of one of the GnRH analogs for presenting continuing medical education lectures on chronic pelvic pain."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1111445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T23:54:10Z","timestamp":1704844450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1111445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,10]]},"references-count":21,"journal-issue":{"issue":"5728","published-print":{"date-parts":[[2005,6,10]]}},"alternative-id":["10.1126\/science.1111445"],"URL":"https:\/\/doi.org\/10.1126\/science.1111445","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,10]]}}}