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Accumulation of mtDNA mutations was not associated with increased markers of oxidative stress or a defect in cellular proliferation, but was correlated with the induction of apoptotic markers, particularly in tissues characterized by rapid cellular turnover. The levels of apoptotic markers were also found to increase during aging in normal mice. Thus, accumulation of mtDNA mutations that promote apoptosis may be a central mechanism driving mammalian aging.<\/jats:p>","DOI":"10.1126\/science.1112125","type":"journal-article","created":{"date-parts":[[2005,7,14]],"date-time":"2005-07-14T18:03:51Z","timestamp":1121364231000},"page":"481-484","source":"Crossref","is-referenced-by-count":1911,"title":["Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging"],"prefix":"10.1126","volume":"309","author":[{"given":"G. 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R. Shelke, C. Leeuwenburgh, FASEB J.17, 494 (2003).","journal-title":"FASEB J."},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099196"},{"key":"e_1_3_1_26_2","unstructured":"We thank J. Warren for stem cell injections S. Kinoshita for histological processing and D. Carlson for support in mouse colony management. Supported by NIH grants AG021905 (T.A.P.) AG18922 (R.W.) AG17994 (C.L.) AG21042 (C.L.) DK48831 GM15431 and RR00095 (J.D.M.) and AG16694 (J.M.S.); by NIH training grants T32 AG00213 (G.C.K.) and T32 GM07601 (W.A.J.); and by American Heart Association predoctoral fellowship 0415166B (A.H.). R.W. and T.A.P. are founders and members of the board of LifeGen Technologies a company focused on nutritional genomics including the impact of nutrients and caloric restriction on the aging process."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1112125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:40:31Z","timestamp":1704836431000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1112125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,15]]},"references-count":25,"journal-issue":{"issue":"5733","published-print":{"date-parts":[[2005,7,15]]}},"alternative-id":["10.1126\/science.1112125"],"URL":"https:\/\/doi.org\/10.1126\/science.1112125","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1027060.327515","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,15]]}}}