{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:12:52Z","timestamp":1791673972345,"version":"4.3.4"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5744","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,9,30]]},"abstract":"<jats:p>\n            Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP\n            <jats:sub>3<\/jats:sub>\n            R2 and IP\n            <jats:sub>3<\/jats:sub>\n            R3) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP\n            <jats:sub>3<\/jats:sub>\n            R2 and IP\n            <jats:sub>3<\/jats:sub>\n            R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a lack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP\n            <jats:sub>3<\/jats:sub>\n            R2 and IP\n            <jats:sub>3<\/jats:sub>\n            R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.\n          <\/jats:p>","DOI":"10.1126\/science.1114110","type":"journal-article","created":{"date-parts":[[2005,9,29]],"date-time":"2005-09-29T21:52:58Z","timestamp":1128030778000},"page":"2232-2234","source":"Crossref","is-referenced-by-count":301,"title":["IP\n            <sub>3<\/sub>\n            Receptor Types 2 and 3 Mediate Exocrine Secretion Underlying Energy Metabolism"],"prefix":"10.1126","volume":"309","author":[{"given":"Akira","family":"Futatsugi","sequence":"first","affiliation":[{"name":"Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan."},{"name":"Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan."},{"name":"Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."},{"name":"Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan."},{"name":"Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan."},{"name":"Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan."},{"name":"Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."},{"name":"Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan."},{"name":"Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki K.","family":"Yamada","sequence":"additional","affiliation":[{"name":"Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan."},{"name":"Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan."},{"name":"Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."},{"name":"Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan."},{"name":"Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Ebisui","sequence":"additional","affiliation":[{"name":"Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan."},{"name":"Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan."},{"name":"Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."},{"name":"Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan."},{"name":"Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan."},{"name":"Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan."},{"name":"Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."},{"name":"Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan."},{"name":"Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Uchida","sequence":"additional","affiliation":[{"name":"Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan."},{"name":"Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan."},{"name":"Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."},{"name":"Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan."},{"name":"Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kitaguchi","sequence":"additional","affiliation":[{"name":"Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan."},{"name":"Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan."},{"name":"Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."},{"name":"Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan."},{"name":"Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Takahashi-Iwanaga","sequence":"additional","affiliation":[{"name":"Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan."},{"name":"Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan."},{"name":"Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."},{"name":"Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan."},{"name":"Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Noda","sequence":"additional","affiliation":[{"name":"Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan."},{"name":"Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan."},{"name":"Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."},{"name":"Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan."},{"name":"Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Aruga","sequence":"additional","affiliation":[{"name":"Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan."},{"name":"Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan."},{"name":"Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."},{"name":"Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan."},{"name":"Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Mikoshiba","sequence":"additional","affiliation":[{"name":"Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan."},{"name":"Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan."},{"name":"Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."},{"name":"Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan."},{"name":"Department of Cell Biology, Japanese Foundation for Cancer Research, 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Nakamura et al., J. Physiol.558.2, 561 (2004).","journal-title":"J. Physiol."},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)37597-X"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.25.15765"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.14.9093"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200210109"},{"key":"e_1_3_1_27_2","unstructured":"We thank Y. Maruyama M. Yamada M. Yamamoto-Hino M. Okubo and M. Kawaguchi for advice and discussion; K. Yamamura and H. Niwa for plasmids; and S. Itohara N. Suzuki H. Saito N. Nagaoka Y. Nakano H. Sagara S. Mori N. Matsumoto and M. Yamada for technical assistance. Supported by the Japan Science and Technology Agency and by grants-in-aid for scientific research (K.M.) from the Ministry of Education Science Sports Culture and Technology of Japan."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1114110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:38:24Z","timestamp":1704854304000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1114110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,30]]},"references-count":26,"journal-issue":{"issue":"5744","published-print":{"date-parts":[[2005,9,30]]}},"alternative-id":["10.1126\/science.1114110"],"URL":"https:\/\/doi.org\/10.1126\/science.1114110","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,30]]}}}