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In addition, regeneration inhibitors trigger the phosphorylation of EGFR in a calcium-dependent manner. Local administration of EGFR inhibitors promotes significant regeneration of injured optic nerve fibers, pointing to a promising therapeutic avenue for enhancing axon regeneration after CNS injury.<\/jats:p>","DOI":"10.1126\/science.1115462","type":"journal-article","created":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T19:57:52Z","timestamp":1128628672000},"page":"106-110","source":"Crossref","is-referenced-by-count":312,"title":["EGFR Activation Mediates Inhibition of Axon Regeneration by Myelin and Chondroitin Sulfate Proteoglycans"],"prefix":"10.1126","volume":"310","author":[{"given":"Vuk","family":"Koprivica","sequence":"first","affiliation":[{"name":"Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA."},{"name":"Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA."},{"name":"Division of Research, Genentech, 1 DNA Way, South San Francisco, CA 94080, 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V.K. is a recipient of NSF predoctoral fellowship. G.Y. is supported by an NIH training grant."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1115462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T23:09:54Z","timestamp":1704841794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1115462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,7]]},"references-count":31,"journal-issue":{"issue":"5745","published-print":{"date-parts":[[2005,10,7]]}},"alternative-id":["10.1126\/science.1115462"],"URL":"https:\/\/doi.org\/10.1126\/science.1115462","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1028608.342222","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,7]]}}}