{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:49:29Z","timestamp":1787701769776,"version":"build-2784847793"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5739","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,8,26]]},"abstract":"<jats:p>\n            In general, the formation and dissociation of solute-solvent complexes have been too rapid to measure without disturbing the thermal equilibrium. We were able to do so with the use of two-dimensional infrared vibrational echo spectroscopy, an ultrafast vibrational analog of two-dimensional nuclear magnetic resonance spectroscopy. The equilibrium dynamics of phenol complexation to benzene in a benzene\u2013carbon tetrachloride solvent mixture were measured in real time by the appearance of off-diagonal peaks in the two-dimensional vibrational echo spectrum of the phenol hydroxyl stretch. The dissociation time constant \u03c4\n            <jats:sub>d<\/jats:sub>\n            for the phenol-benzene complex was 8 picoseconds. Adding two electron-donating methyl groups to the benzene nearly tripled the value of \u03c4\n            <jats:sub>d<\/jats:sub>\n            and stabilized the complex, whereas bromobenzene, with an electron-withdrawing bromo group, formed a slightly weaker complex with a slightly lower \u03c4\n            <jats:sub>d<\/jats:sub>\n            . The spectroscopic method holds promise for studying a wide variety of other fast chemical exchange processes.\n          <\/jats:p>","DOI":"10.1126\/science.1116213","type":"journal-article","created":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T00:44:05Z","timestamp":1123202645000},"page":"1338-1343","source":"Crossref","is-referenced-by-count":429,"title":["Ultrafast Dynamics of Solute-Solvent Complexation Observed at Thermal Equilibrium in Real Time"],"prefix":"10.1126","volume":"309","author":[{"given":"Junrong","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Chemistry, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungwon","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Asbury","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan R.","family":"Piletic","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Fayer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"C. Reichardt Solvents and Solvent Effects in Organic Chemistry (Wiley-VCH Weinheim Germany ed. 3 2003).","DOI":"10.1002\/3527601791"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1696308"},{"key":"e_1_3_2_4_2","unstructured":"S. N. Vinogradov R. H. Linnell Hydrogen Bonding (Van Nostrand Reinhold New York 1971)."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.438208"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00515a053"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr030413t"},{"key":"e_1_3_2_8_2","first-page":"8030","volume":"105","year":"2001","unstructured":"N. Demirdoven, M. Khalil, O. Golonzka, A. Tokmakoff, J. Phys. Chem. A105, 8030 (2001).","journal-title":"J. Phys. Chem. A"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp0449511"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.91.237402"},{"key":"e_1_3_2_11_2","unstructured":"H.-J. Schneider A. K. Yatsimirsky Principles and Methods in Supramolecular Chemistry (Wiley Chichester UK 2000)."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200390319"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.453608"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.1993.0122"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp0208992"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pc.22.100171.002023"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2003.12.035"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physchem.51.1.691"},{"key":"e_1_3_2_19_2","unstructured":"S. Mukamel Principles of Nonlinear Optical Spectroscopy (Oxford Univ. Press New York 1995)."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.86.2154"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1818107"},{"key":"e_1_3_2_22_2","first-page":"174501(9)","volume":"122","year":"2005","unstructured":"H.-S. Tan, I. R. Piletic, M. D. Fayer, J. Chem. Phys.122, 174501(9) (2005).","journal-title":"J. Chem. Phys."},{"key":"e_1_3_2_23_2","unstructured":"We thank J. I. Brauman for insightful discussions J. Xie for his aid in chemical preparation and H.-S. Tan for his aid in pump-probe measurements. Supported by grants from the Air Force Office of Scientific Research (F49620-01-1-0018) and NSF Division of Materials Research (DMR-0332692)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1116213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:28:54Z","timestamp":1704857334000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1116213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,26]]},"references-count":22,"journal-issue":{"issue":"5739","published-print":{"date-parts":[[2005,8,26]]}},"alternative-id":["10.1126\/science.1116213"],"URL":"https:\/\/doi.org\/10.1126\/science.1116213","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,26]]}}}