{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:23:10Z","timestamp":1792794190137,"version":"4.5.0"},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5744","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,9,30]]},"abstract":"<jats:p>Intraoperative electrical stimulation, which temporarily inactivates restricted regions during brain surgery, can map cognitive functions in humans with spatiotemporal resolution unmatched by other methods. Using this technique, we found that stimulation of the right inferior parietal lobule or the caudal superior temporal gyrus, but not of its rostral portion, determined rightward deviations on line bisection. However, the strongest shifts occurred with subcortical stimulation. Fiber tracking identified the stimulated site as a section of the superior occipitofrontal fasciculus, a poorly known parietal-frontal pathway. These findings suggest that parietal-frontal communication is necessary for the symmetrical processing of the visual scene.<\/jats:p>","DOI":"10.1126\/science.1116251","type":"journal-article","created":{"date-parts":[[2005,9,29]],"date-time":"2005-09-29T17:52:58Z","timestamp":1128016378000},"page":"2226-2228","source":"Crossref","is-referenced-by-count":602,"title":["Direct Evidence for a Parietal-Frontal Pathway Subserving Spatial Awareness in Humans"],"prefix":"10.1126","volume":"309","author":[{"given":"Michel Thiebaut","family":"de Schotten","sequence":"first","affiliation":[{"name":"INSERM Unit 610, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."},{"name":"Department of Neurosurgery, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."},{"name":"Department of Neuroimagery, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."},{"name":"Department of Neurology, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Urbanski","sequence":"additional","affiliation":[{"name":"INSERM Unit 610, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."},{"name":"Department of Neurosurgery, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."},{"name":"Department of Neuroimagery, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."},{"name":"Department of Neurology, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, 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Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."},{"name":"Department of Neurology, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Dubois","sequence":"additional","affiliation":[{"name":"INSERM Unit 610, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."},{"name":"Department of Neurosurgery, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."},{"name":"Department of Neuroimagery, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, France."},{"name":"Department of Neurology, Assistance Publique\u2013Ho\u0302pitaux de Paris, Ho\u0302pital de la Salpe\u0302trie\u0300re, 75013 Paris, 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France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0482"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.2.160"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(01)00065-3"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.5.509"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/02643299008253438"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.3.841"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0822"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg200"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn755"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077395"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/35135"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh076"},{"key":"e_1_3_1_14_2","unstructured":"A. D. Milner M. A. Goodale The Visual Brain in Action (Oxford Univ. Press Oxford 1995)."},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/35086057"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200312020-00021"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh423"},{"key":"e_1_3_1_18_2","unstructured":"CAL and SB attended clinical observation because of epileptic seizures. They showed no abnormality on preoperative neurological and neuropsychological examination consistent with the slowly infiltrative character of low-grade gliomas whose clinical presentation rarely includes signs of focal brain disease other than epilepsy. In particular there were no signs of neglect on paper-and-pencil tests (table S1). Intraoperative electrical stimulation was well tolerated and the patients reported no abnormal visual sensations. They bisected horizontal lines with their left dominant hand during brain surgery ( 28 ). Eight healthy left-handed subjects (mean age 31 years; SD 5.3; range 26 to 38) served as controls. They performed 30 line bisections each with the same test material and in a body position similar to that of the patients. Our patients' baseline performance was well within the range of the controls' performance (mean \u00b1 SD 0.28 \u00b1 2.39 mm) as well as that of 10 strongly left-handed normal individuals tested in another study ( 29 ) (mean \u00b1 SD \u20131.50 \u00b1 3.66 mm). In an unselected population of 204 patients with right brain damage ( 2 ) 5 of the 10 patients with the strongest left-handedness deviated rightward on 20-cm lines as compared to controls ( 29 ) a frequency of impairment similar to that showed by right-handed patients ( 2 )."},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1136"},{"key":"e_1_3_1_20_2","unstructured":"The neurosurgeon stopped the resection after stimulation of the region labeled as 42 (Fig. 2A). As a consequence region 42 corresponded to the deepest point on the floor of the rostral-superior part of the surgical cavity and was thus easily identified on postoperative anatomical MRI scans. The white matter tract underlying region 42 was identified by overlapping the MRI scans with the DTI scans (fig. S1) (Fig. 2 C and D)."},{"key":"e_1_3_1_21_2","first-page":"31","year":"2002","unstructured":"M. Petrides, D. N. Pandya, in Principles of Frontal Lobe Function, D. T. Stuss, R. T. Knight, Eds. (Oxford Univ. Press, Oxford, 2002), pp. 31\u201350.","journal-title":"Principles of Frontal Lobe Function"},{"key":"e_1_3_1_22_2","unstructured":"The superior occipitofrontal fasciculus is a poorly known long association pathway. It terminates rostrally in the lateral prefrontal cortex of the inferior and middle frontal gyri ( 18 ). Its caudal terminations are less known ( 18 30 ) but despite its name derived from early descriptions ( 31 ) the superior occipitofrontal fasciculus seems to terminate caudally in the superior parietal gyrus ( 18 ) and in the intraparietal sulcus [( 30 ) p. 367]."},{"key":"e_1_3_1_23_2","unstructured":"We used line bisection because it is an easy task for patients to perform and allows repeated assessments in the time scale required by intraoperative testing. Bisection of centrally presented 20-cm lines correlates positively and significantly with cancellation tests and is a good predictor of clinical neglect as assessed by standardized scales ( 2 28 )."},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2004.10.022"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.9.1647"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1005"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(01)00087-2"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh244"},{"key":"e_1_3_1_29_2","unstructured":"See supporting data on Science Online."},{"key":"e_1_3_1_30_2","first-page":"1385","volume":"157","year":"2001","unstructured":"M. Rousseaux et al., Rev. Neurol. (Paris)157, 1385 (2001).","journal-title":"Rev. Neurol. (Paris)"},{"key":"e_1_3_1_31_2","doi-asserted-by":"crossref","unstructured":"R. Nieuwenhuys J. Voogd C. van Huijzen The Human Central Nervous System: A Synopsis and Atlas (Springer-Verlag New York 1988).","DOI":"10.1007\/978-3-662-10343-2"},{"key":"e_1_3_1_32_2","unstructured":"M. J. D\u00e9jerine Anatomie des Centres Nerveux (Rueff Paris 1895)."},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(01)00224-X"},{"key":"e_1_3_1_34_2","unstructured":"We thank the patients for their cooperation; P. Gatignol for help with intraoperative testing; J. Chiras and the Department of Neuroradiology of the Salp\u00eatri\u00e8re Hospital for MRI acquisitions; S. Kinkingnehun C. Delmaire J. B. Pochon L. Thivard and the staff of BrainVISA software for technical support for image analysis; and P. Azouvi and the members of the Groupe d'Etude sur la R\u00e9\u00e9ducation et l'Evaluation de la N\u00e9gligence (GEREN) for permission to use data from GEREN studies ( 2 29 )."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1116251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:38:53Z","timestamp":1704836333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1116251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,30]]},"references-count":33,"journal-issue":{"issue":"5744","published-print":{"date-parts":[[2005,9,30]]}},"alternative-id":["10.1126\/science.1116251"],"URL":"https:\/\/doi.org\/10.1126\/science.1116251","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1028730.341277","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,30]]}}}