{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:58:25Z","timestamp":1792717105150,"version":"4.5.0"},"reference-count":14,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5758","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2006,1,13]]},"abstract":"<jats:p>The comprehensive yeast two-hybrid analysis of intraviral protein interactions in two members of the herpesvirus family, Kaposi sarcoma\u2013associated herpesvirus (KSHV) and varicella-zoster virus (VZV), revealed 123 and 173 interactions, respectively. Viral protein interaction networks resemble single, highly coupled modules, whereas cellular networks are organized in separate functional submodules. Predicted and experimentally verified interactions between KSHV and human proteins were used to connect the viral interactome into a prototypical human interactome and to simulate infection. The analysis of the combined system showed that the viral network adopts cellular network features and that protein networks of herpesviruses and possibly other intracellular pathogens have distinguishing topologies.<\/jats:p>","DOI":"10.1126\/science.1116804","type":"journal-article","created":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T20:52:57Z","timestamp":1134075177000},"page":"239-242","source":"Crossref","is-referenced-by-count":354,"title":["Herpesviral Protein Networks and Their Interaction with the Human Proteome"],"prefix":"10.1126","volume":"311","author":[{"given":"Peter","family":"Uetz","sequence":"first","affiliation":[{"name":"Institut fu\u0308r Genetik, Forschungszentrum Karlsruhe, Postfach 3640, Karlsruhe, D-76021 Germany."},{"name":"Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139 USA."},{"name":"Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkofer-strasse 9a, 80336 Mu\u0308nchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-An","family":"Dong","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Genetik, Forschungszentrum Karlsruhe, Postfach 3640, Karlsruhe, D-76021 Germany."},{"name":"Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139 USA."},{"name":"Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkofer-strasse 9a, 80336 Mu\u0308nchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Zeretzke","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Genetik, Forschungszentrum Karlsruhe, Postfach 3640, Karlsruhe, D-76021 Germany."},{"name":"Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139 USA."},{"name":"Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkofer-strasse 9a, 80336 Mu\u0308nchen, 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Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Roupelieva","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Genetik, Forschungszentrum Karlsruhe, Postfach 3640, Karlsruhe, D-76021 Germany."},{"name":"Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139 USA."},{"name":"Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkofer-strasse 9a, 80336 Mu\u0308nchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietlind","family":"Rose","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Genetik, Forschungszentrum Karlsruhe, Postfach 3640, Karlsruhe, D-76021 Germany."},{"name":"Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139 USA."},{"name":"Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkofer-strasse 9a, 80336 Mu\u0308nchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Even","family":"Fossum","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Genetik, Forschungszentrum Karlsruhe, Postfach 3640, Karlsruhe, D-76021 Germany."},{"name":"Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139 USA."},{"name":"Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkofer-strasse 9a, 80336 Mu\u0308nchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u0308rgen","family":"Haas","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Genetik, Forschungszentrum Karlsruhe, Postfach 3640, Karlsruhe, D-76021 Germany."},{"name":"Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139 USA."},{"name":"Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkofer-strasse 9a, 80336 Mu\u0308nchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2583304"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-9-1759"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5439.509"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/30918"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065103"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.029"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04209"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/82360"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090289"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091403"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-9-r63"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.080078197"},{"key":"e_1_3_2_15_2","unstructured":"This work was supported by grants provided by Bayerisches Staatsministerium f\u00fcr Wissenschaft Forschung und Kunst (BayGene) Deutsche Forschungsgemeinschaft (SFB 576) Sander-Stiftung (1999.096.1) Helmholtz Gemeinschaft (P.U. and Y.-A.D.) and LMU M\u00fcnchen (FoeFoLe). We thank A. Arvin Y. Chang D. Ganem S.-J. Gao W. Hammerschmidt Y. Kawaguchi U. Koszinowski P. Moore B. Moss F. Neipel P. Pitha-Rowe T. Schulz B. Sodeik C. Wood and Y. Yuan for plasmids cosmids bacterial artificial chromosomes and viruses. This manuscript is dedicated to C.A.."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1116804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:33:16Z","timestamp":1704835996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1116804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,13]]},"references-count":14,"journal-issue":{"issue":"5758","published-print":{"date-parts":[[2006,1,13]]}},"alternative-id":["10.1126\/science.1116804"],"URL":"https:\/\/doi.org\/10.1126\/science.1116804","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1029659.347512","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,13]]}}}