{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:16:40Z","timestamp":1791335800395,"version":"4.3.1"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5743","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,9,23]]},"abstract":"<jats:p>\n            Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial signaling centers, the enamel knots, form at future cusp positions and are the first signs of cusp patterns that distinguish species. We report that\n            <jats:italic>ectodin<\/jats:italic>\n            , a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a \u201cnegative\u201d image of mouse enamel knots. Furthermore, we show that\n            <jats:italic>ectodin<\/jats:italic>\n            -deficient mice have enlarged enamel knots, highly altered cusp patterns, and extra teeth. Unlike in normal teeth, excess BMP accelerates patterning in\n            <jats:italic>ectodin<\/jats:italic>\n            -deficient teeth. We propose that\n            <jats:italic>ectodin<\/jats:italic>\n            is critical for robust spatial delineation of enamel knots and cusps.\n          <\/jats:p>","DOI":"10.1126\/science.1116848","type":"journal-article","created":{"date-parts":[[2005,9,22]],"date-time":"2005-09-22T20:58:23Z","timestamp":1127422703000},"page":"2067-2070","source":"Crossref","is-referenced-by-count":260,"title":["Regulation of Mammalian Tooth Cusp Patterning by Ectodin"],"prefix":"10.1126","volume":"309","author":[{"given":"Yoshiaki","family":"Kassai","sequence":"first","affiliation":[{"name":"Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto 606-8501, Japan."},{"name":"Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, Post Office Box 56, University of Helsinki, FIN-00014 Helsinki, Finland."},{"name":"Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Okazaki 444-8787, 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Evans H. Kettunen M. M\u00e4kinen I. Salazar-Ciudad R. Santalahti and P. C. Wright for comments or technical help."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1116848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:50:15Z","timestamp":1704855015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1116848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,23]]},"references-count":30,"journal-issue":{"issue":"5743","published-print":{"date-parts":[[2005,9,23]]}},"alternative-id":["10.1126\/science.1116848"],"URL":"https:\/\/doi.org\/10.1126\/science.1116848","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,23]]}}}