{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:16:02Z","timestamp":1791198962907,"version":"4.1.0"},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5752","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2005,11,25]]},"abstract":"<jats:p>Drug-dependent neural plasticity related to drug addiction and schizophrenia can be modeled in animals as behavioral sensitization, which is induced by repeated noncontingent or self-administration of many drugs of abuse. Molecular mechanisms that are critical for behavioral sensitization have yet to be specified. Long-term depression (LTD) of \u03b1-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor (AMPAR)\u2013mediated synaptic transmission in the brain has been proposed as a cellular substrate for learning and memory. The expression of LTD in the nucleus accumbens (NAc) required clathrin-dependent endocytosis of postsynaptic AMPARs. NAc LTD was blocked by a dynamin-derived peptide that inhibited clathrin-mediated endocytosis or by a GluR2-derived peptide that blocked regulated AMPAR endocytosis. Systemic or intra-NAc infusion of the membrane-permeable GluR2 peptide prevented the expression of amphetamine-induced behavioral sensitization in the rat.<\/jats:p>","DOI":"10.1126\/science.1116894","type":"journal-article","created":{"date-parts":[[2005,11,25]],"date-time":"2005-11-25T10:48:06Z","timestamp":1132915686000},"page":"1340-1343","source":"Crossref","is-referenced-by-count":250,"title":["Nucleus Accumbens Long-Term Depression and the Expression of Behavioral Sensitization"],"prefix":"10.1126","volume":"310","author":[{"given":"Karen","family":"Brebner","sequence":"first","affiliation":[{"name":"Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak Pan","family":"Wong","sequence":"additional","affiliation":[{"name":"Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidong","family":"Liu","sequence":"additional","affiliation":[{"name":"Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitao","family":"Liu","sequence":"additional","affiliation":[{"name":"Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Campsall","sequence":"additional","affiliation":[{"name":"Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Gray","sequence":"additional","affiliation":[{"name":"Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Phelps","sequence":"additional","affiliation":[{"name":"Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony G.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."},{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(93)90013-P"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246669"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2003.11.001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.046"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00021-0"},{"key":"e_1_3_2_7_2","first-page":"43","volume":"20","year":"2001","unstructured":"J. L. Cornish, P. W. Kalivas, J. Addict. Dis.20, 43 (2001).","journal-title":"J. Addict. Dis."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/35094560"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(97)00090-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.02.005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90902-N"},{"key":"e_1_3_2_12_2","first-page":"690","volume":"270","year":"1994","unstructured":"M. Perugini, P. Vezina, J. Pharmacol. Exp. Ther.270, 690 (1994).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn757"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000637"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81119-8"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00640-8"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-15-05581.2000"},{"key":"e_1_3_2_18_2","unstructured":"Single-letter abbreviations for the amino acid residues areasfollows:A Ala; C Cys; D Asp; E Glu; F Phe; G Gly; H His; I Ile; K Lys; L Leu; M Met; N Asn; P Pro; Q Gln; R Arg; S Ser; T Thr; V Val; W Trp; and Y Tyr."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70297-0"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81066-1"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80852-1"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600126"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C400199200"},{"key":"e_1_3_2_24_2","unstructured":"Hippocampal CA1 LTP was induced in rat slice preparations by pairing Schaffer collateral stimulation (200 pulses stimulation at 2 Hz) with postsynaptic depolarization of the cell to \u20135 mV from a holding membrane potential of \u201360 mV. LTP was reliably induced in cells recorded with pipette solutions supplemented with or without GluR2 3Y peptide [normalized EPSC amplitude: 164 \u00b1 22% for GluR2 3Y (100 \u03bcg\/ml n = 7) versus 168 \u00b1 18% for control ( n = 7 P > 0.5)]. Thus the GluR2 3Y peptide appears not to affect LTP expression."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5433.1569"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072873"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/81823"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(95)00153-0"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(94)90101-5"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00048-0"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300748"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.06.017"},{"key":"e_1_3_2_34_2","unstructured":"This work was supported by the Brain Repair Program of Neuroscience Canada (A.G.P and Y.T.W.) and the Canadian Institutes of Health Research (CIHR). Y.T.W. is an international research scholar of the Howard Hughes Medical Institute and T.P.W. is a Research Fellow of CIHR. We gratefully acknowledge useful initial discussions with Y. Dong and advice from N. Gorelova for NAc slice preparation and from M. Thomas and A. Bonci on recording of NAc LTD in slices."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1116894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:09:33Z","timestamp":1704834573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1116894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,25]]},"references-count":33,"journal-issue":{"issue":"5752","published-print":{"date-parts":[[2005,11,25]]}},"alternative-id":["10.1126\/science.1116894"],"URL":"https:\/\/doi.org\/10.1126\/science.1116894","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1029439.345416","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,25]]}}}