{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:32:58Z","timestamp":1789205578057,"version":"build-2803163510"},"reference-count":10,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5764","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2006,2,24]]},"abstract":"<jats:p>The emergence of chronic wasting disease (CWD) in deer and elk in an increasingly wide geographic area, as well as the interspecies transmission of bovine spongiform encephalopathy to humans in the form of variant Creutzfeldt Jakob disease, have raised concerns about the zoonotic potential of CWD. Because meat consumption is the most likely means of exposure, it is important to determine whether skeletal muscle of diseased cervids contains prion infectivity. Here bioassays in transgenic mice expressing cervid prion protein revealed the presence of infectious prions in skeletal muscles of CWD-infected deer, demonstrating that humans consuming or handling meat from CWD-infected deer are at risk to prion exposure.<\/jats:p>","DOI":"10.1126\/science.1122864","type":"journal-article","created":{"date-parts":[[2006,1,26]],"date-time":"2006-01-26T21:03:11Z","timestamp":1138309391000},"page":"1117-1117","source":"Crossref","is-referenced-by-count":194,"title":["Prions in Skeletal Muscles of Deer with Chronic Wasting Disease"],"prefix":"10.1126","volume":"311","author":[{"given":"Rachel C.","family":"Angers","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Neurology, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA."},{"name":"Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn R.","family":"Browning","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Neurology, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA."},{"name":"Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya S.","family":"Seward","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Neurology, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA."},{"name":"Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina J.","family":"Sigurdson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Neurology, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA."},{"name":"Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Neurology, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA."},{"name":"Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Hoover","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Neurology, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA."},{"name":"Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn C.","family":"Telling","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Neurology, University of Kentucky, Lexington, KY 40536, USA."},{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA."},{"name":"Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052707499"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.23.13345-13350.2004"},{"key":"e_1_3_2_4_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/431602"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1055"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-110"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-1-78"},{"key":"e_1_3_2_9_2","first-page":"4883","volume":"21","year":"1980","unstructured":"S. B. Prusiner et al., Biochemistry21, 4883 (1980).","journal-title":"Biochemistry"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63907-7"},{"key":"e_1_3_2_11_2","unstructured":"This work was supported by grants from the U.S. Public Health Service grant 2RO1 NS040334-04 from the National Institute of Neurological Disorders and Stroke and grant N01-AI-25491 from the National Institute of Allergy and Infectious Diseases."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1122864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:10:48Z","timestamp":1704834648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1122864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,24]]},"references-count":10,"journal-issue":{"issue":"5764","published-print":{"date-parts":[[2006,2,24]]}},"alternative-id":["10.1126\/science.1122864"],"URL":"https:\/\/doi.org\/10.1126\/science.1122864","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1031675.493001","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1031675.367792","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,24]]}}}