{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:43:53Z","timestamp":1792795433161,"version":"4.5.0"},"reference-count":72,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5787","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2006,8,4]]},"abstract":"<jats:p>Almost every vertebrate cell has a specialized cell surface projection called a primary cilium. Although these structures were first described more than a century ago, the full scope of their functions remains poorly understood. Here, we review emerging evidence that in addition to their well-established roles in sight, smell, and mechanosensation, primary cilia are key participants in intercellular signaling. This new appreciation of primary cilia as cellular antennae that sense a wide variety of signals could help explain why ciliary defects underlie such a wide range of human disorders, including retinal degeneration, polycystic kidney disease, Bardet-Biedl syndrome, and neural tube defects.<\/jats:p>","DOI":"10.1126\/science.1124534","type":"journal-article","created":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T22:04:15Z","timestamp":1154642655000},"page":"629-633","source":"Crossref","is-referenced-by-count":1052,"title":["The Primary Cilium as the Cell's Antenna: Signaling at a Sensory Organelle"],"prefix":"10.1126","volume":"313","author":[{"given":"Veena","family":"Singla","sequence":"first","affiliation":[{"name":"Program in Developmental and Stem Cell Biology, and Diabetes Center, University of California, San Francisco, CA 94143\u20130525, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy F.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Program in Developmental and Stem Cell Biology, and Diabetes Center, University of California, San Francisco, CA 94143\u20130525, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm952"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.6.1517"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1186"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.4.979"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00438"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.54.2.246"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81705-5"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2005.04.008"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.09.051"},{"key":"e_1_3_1_11_2","unstructured":"Primary Cilium Resource Page List of Cells (www.bowserlab.org\/primarycilia\/cilialist.html)."},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90418-X"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.tb18564.x"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07422.x"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/325442a0"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11068-005-5045-9"},{"key":"e_1_3_1_17_2","first-page":"33","volume":"19","year":"1977","unstructured":"A. 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We thank R. Bloodgood K. Corbit and W. Marshall for helpful comments and A. Alvarez-Buylla Y.-G. Han J. Garcia-Verdugo Z. Mirzadeh J. Feldman P. Scherz D. Stainier and J. Wallingford for providing images used in Fig. 1. Supported by NIH grant R21DK69423 the March of Dimes NSF (V.S.) and the UCSF Fellows Program (J.F.R.)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1124534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:24:29Z","timestamp":1704853469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1124534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,4]]},"references-count":72,"journal-issue":{"issue":"5787","published-print":{"date-parts":[[2006,8,4]]}},"alternative-id":["10.1126\/science.1124534"],"URL":"https:\/\/doi.org\/10.1126\/science.1124534","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,4]]}}}