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Analysis of the viral linear DNA genome suggests that its evolution involved direct descent and DNA end-region recombination events. Knowing the sequences will help understand the viral proteome and improve diagnostic test precision, therapeutics, and systems for their assessment.<\/jats:p>","DOI":"10.1126\/science.1125134","type":"journal-article","created":{"date-parts":[[2006,7,28]],"date-time":"2006-07-28T00:40:18Z","timestamp":1154047218000},"page":"807-812","source":"Crossref","is-referenced-by-count":176,"title":["Genome Sequence Diversity and Clues to the Evolution of Variola (Smallpox) Virus"],"prefix":"10.1126","volume":"313","author":[{"given":"Joseph J.","family":"Esposito","sequence":"first","affiliation":[{"name":"Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."},{"name":"Poxvirus and Rabies Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."},{"name":"Imperial College London, St. Mary's Campus, London, W2 1PG, UK."},{"name":"Bundeswehr Institute of Microbiology, Munich, Germany 80937."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Sammons","sequence":"additional","affiliation":[{"name":"Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."},{"name":"Poxvirus and Rabies Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."},{"name":"Imperial College London, St. Mary's Campus, London, W2 1PG, UK."},{"name":"Bundeswehr Institute of Microbiology, Munich, Germany 80937."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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L. Patton M. Khristova D. Carroll S. Reeder R. Morey and R. Galloway for expert technical assistance; C. Chesley for grammatical advice; the Poxvirus Bioinformatics Resource Center (www.poxvirus.org and www.biovirus.org) for poxvirus orthologous clusters (POCs) and viral orthologous clusters (VOCs) source codes; J. Rozas for DnaSP source code; A. J. Gibbs M. J. Gibbs and J. S. Armstrong for SiScan; and K. R. Dumbell and F. Fenner for smallpox history information. D.G. is funded by Atlanta Research and Education Foundation Decatur GA. Sequence data are deposited under GenBank accession numbers AY313847 DQ437580-DQ437594 and DQ441416-DQ441448."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1125134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:00:42Z","timestamp":1704855642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1125134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,11]]},"references-count":42,"journal-issue":{"issue":"5788","published-print":{"date-parts":[[2006,8,11]]}},"alternative-id":["10.1126\/science.1125134"],"URL":"https:\/\/doi.org\/10.1126\/science.1125134","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,11]]}}}