{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:39:14Z","timestamp":1791203954941,"version":"4.2.0"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5783","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2006,7,7]]},"abstract":"<jats:p>\n                    Natural populations of beach mice exhibit a characteristic color pattern, relative to their mainland conspecifics, driven by natural selection for crypsis. We identified a derived, charge-changing amino acid mutation in the melanocortin-1 receptor (\n                    <jats:italic>Mc1r<\/jats:italic>\n                    ) in beach mice, which decreases receptor function. In genetic crosses, allelic variation at\n                    <jats:italic>Mc1r<\/jats:italic>\n                    explains 9.8% to 36.4% of the variation in seven pigmentation traits determining color pattern. The derived\n                    <jats:italic>Mc1r<\/jats:italic>\n                    allele is present in Florida's Gulf Coast beach mice but not in Atlantic coast mice with similar light coloration, suggesting that different molecular mechanisms are responsible for convergent phenotypic evolution. Here, we link a single mutation in the coding region of a pigmentation gene to adaptive quantitative variation in the wild.\n                  <\/jats:p>","DOI":"10.1126\/science.1126121","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T16:58:02Z","timestamp":1152205082000},"page":"101-104","source":"Crossref","is-referenced-by-count":596,"title":["A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern"],"prefix":"10.1126","volume":"313","author":[{"given":"Hopi E.","family":"Hoekstra","sequence":"first","affiliation":[{"name":"Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA."},{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA."},{"name":"Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Hirschmann","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA."},{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA."},{"name":"Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Bundey","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA."},{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA."},{"name":"Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Insel","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA."},{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA."},{"name":"Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet P.","family":"Crossland","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA."},{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA."},{"name":"Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1086\/285437","volume":"140","year":"1992","unstructured":"H. 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Parkinson A. Suazo and M. Wooten. Comments by the Hoekstra Lab M. Hofreiter J. Kohn K. Peichel T. Price H. Roempler J. Stinchcombe and anonymous reviewers improved this manuscript. J.P.C. is supported by NIH-P40-RR14279 and NSF-DBI-0444165. This research is funded by NSF-DEB-0344710 to H.E.H. GenBank Accession Numbers: DQ482848 DQ482850."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1126121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T20:58:47Z","timestamp":1704833927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1126121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,7]]},"references-count":22,"journal-issue":{"issue":"5783","published-print":{"date-parts":[[2006,7,7]]}},"alternative-id":["10.1126\/science.1126121"],"URL":"https:\/\/doi.org\/10.1126\/science.1126121","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1033182.387800","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1033182.375160","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1033182.375109","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,7]]}}}