{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:41:16Z","timestamp":1792215676545,"version":"4.4.0"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5784","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2006,7,14]]},"abstract":"<jats:p>The vesicular stomatitis virus has an atypical membrane fusion glycoprotein (G) exhibiting a pH-dependent equilibrium between two forms at the virus surface. Membrane fusion is triggered during the transition from the high- to low-pH form. The structure of G in its low-pH form shows the classic hairpin conformation observed in all other fusion proteins in their postfusion conformation, in spite of a novel fold combining features of fusion proteins from classes I and II. The structure provides a framework for understanding the reversibility of the G conformational change. Unexpectedly, G is homologous to gB of herpesviruses, which raises important questions on viral evolution.<\/jats:p>","DOI":"10.1126\/science.1127683","type":"journal-article","created":{"date-parts":[[2006,7,13]],"date-time":"2006-07-13T22:14:54Z","timestamp":1152828894000},"page":"187-191","source":"Crossref","is-referenced-by-count":399,"title":["Crystal Structure of the Low-pH Form of the Vesicular Stomatitis Virus Glycoprotein G"],"prefix":"10.1126","volume":"313","author":[{"given":"Ste\u0301phane","family":"Roche","sequence":"first","affiliation":[{"name":"CNRS, Unite\u0301 Mixte de Recherche (UMR) 2472, Institut Fe\u0301de\u0301ratif de Recherche (IFR) 115, Virologie Mole\u0301culaire et Structurale, 91198, Gif sur Yvette, France; Institut National de la Recherche Agronomique (INRA), UMR1157, Virologie Mole\u0301culaire et Structurale, 91198, Gif sur Yvette, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ste\u0301phane","family":"Bressanelli","sequence":"additional","affiliation":[{"name":"CNRS, Unite\u0301 Mixte de Recherche (UMR) 2472, Institut Fe\u0301de\u0301ratif de Recherche (IFR) 115, Virologie Mole\u0301culaire et Structurale, 91198, Gif sur Yvette, France; Institut National de la Recherche Agronomique (INRA), UMR1157, Virologie Mole\u0301culaire et Structurale, 91198, Gif sur Yvette, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fe\u0301lix A.","family":"Rey","sequence":"additional","affiliation":[{"name":"CNRS, Unite\u0301 Mixte de Recherche (UMR) 2472, Institut Fe\u0301de\u0301ratif de Recherche (IFR) 115, Virologie Mole\u0301culaire et Structurale, 91198, Gif sur Yvette, France; Institut National de la Recherche Agronomique (INRA), UMR1157, Virologie Mole\u0301culaire et Structurale, 91198, Gif sur Yvette, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Gaudin","sequence":"additional","affiliation":[{"name":"CNRS, Unite\u0301 Mixte de Recherche (UMR) 2472, Institut Fe\u0301de\u0301ratif de Recherche (IFR) 115, Virologie Mole\u0301culaire et Structurale, 91198, Gif sur Yvette, France; Institut National de la Recherche Agronomique (INRA), UMR1157, Virologie Mole\u0301culaire et Structurale, 91198, Gif sur Yvette, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/289366a0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/371037a0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04322"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503989102"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(01)00581-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0596-465"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80159-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403760200"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/375291a0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0832193100"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00303-8"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02165"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02239"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600064"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00457a028"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.3.1365-1372.1993"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.4.2186-2193.1994"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.3.1435-1443.1995"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-5-1221"},{"key":"e_1_3_2_21_2","first-page":"379","volume":"34","year":"2000","unstructured":"Y. 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Delano the PyMOL Molecular Graphics System (2002)."},{"key":"e_1_3_2_40_2","unstructured":"We thank A. Flamand for her constant support of this project; J. Lepault R. Ruigrok M. Knossow A. Benmansour C. Tuffereau and D. Blondel for helpful discussions at different stages of this work; C. Maheu for virus purification; and S. Harrison and K. Heldwein for sharing information before publication. Data collection was performed in part at the Swiss Light Source Paul Scherrer Institut Villigen Switzerland and at the European Synchrotron Radiation Facility Grenoble France. We gratefully acknowledge the help in data collection of T. Tomizaki (beamline X06SA SLS); C. Petosa (beamline ID14-1 ESRF); and S. Duquerroy F. Ternois and G. Squires. We thank B. Gigant and I. Gallay for the use of rotating anode sources for crystal testing. We acknowledge support from the CNRS and INRA the CNRS program \u201cPhysique et Chimie du Vivant \u201d the INRA Animal Health Department program \u201cLes virus des animaux et leurs interactions avec la cellule \u201d the Minist\u00e8re de l'\u00e9ducation nationale de la recherche et de la technologie (MENRT) program \u201cACI blanche \u201d and the Agence National de la Recherche (ANR) program."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1127683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:25:17Z","timestamp":1704853517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1127683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,14]]},"references-count":39,"journal-issue":{"issue":"5784","published-print":{"date-parts":[[2006,7,14]]}},"alternative-id":["10.1126\/science.1127683"],"URL":"https:\/\/doi.org\/10.1126\/science.1127683","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,14]]}}}