{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:35:28Z","timestamp":1792730128464,"version":"4.5.0"},"reference-count":32,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5786","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2006,7,28]]},"abstract":"<jats:p>Snake or honeybee envenomation can cause substantial morbidity and mortality, and it has been proposed that the activation of mast cells by snake or insect venoms can contribute to these effects. We show, in contrast, that mast cells can significantly reduce snake-venom\u2013induced pathology in mice, at least in part by releasing carboxypeptidase A and possibly other proteases, which can degrade venom components. Mast cells also significantly reduced the morbidity and mortality induced by honeybee venom. These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms.<\/jats:p>","DOI":"10.1126\/science.1128877","type":"journal-article","created":{"date-parts":[[2006,7,27]],"date-time":"2006-07-27T21:08:36Z","timestamp":1154034516000},"page":"526-530","source":"Crossref","is-referenced-by-count":319,"title":["Mast Cells Can Enhance Resistance to Snake and Honeybee Venoms"],"prefix":"10.1126","volume":"313","author":[{"given":"Martin","family":"Metz","sequence":"first","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305\u20135324, USA."},{"name":"Department of Molecular Biosciences, Swedish University of Agricultural Sciences, The Biomedical Center, Box 575, 751 23 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian M.","family":"Piliponsky","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305\u20135324, USA."},{"name":"Department of Molecular Biosciences, Swedish University of Agricultural Sciences, The Biomedical Center, Box 575, 751 23 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305\u20135324, USA."},{"name":"Department of Molecular Biosciences, Swedish University of Agricultural Sciences, The Biomedical Center, Box 575, 751 23 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Lammel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305\u20135324, USA."},{"name":"Department of Molecular Biosciences, Swedish University of Agricultural Sciences, The Biomedical Center, Box 575, 751 23 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"A\u030abrink","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305\u20135324, USA."},{"name":"Department of Molecular Biosciences, Swedish University of Agricultural Sciences, The Biomedical Center, Box 575, 751 23 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Pejler","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305\u20135324, USA."},{"name":"Department of Molecular Biosciences, Swedish University of Agricultural Sciences, The Biomedical Center, Box 575, 751 23 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305\u20135324, USA."},{"name":"Department of Molecular Biosciences, Swedish University of Agricultural Sciences, The Biomedical Center, Box 575, 751 23 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305\u20135324, USA."},{"name":"Department of Molecular Biosciences, Swedish University of Agricultural Sciences, The Biomedical Center, Box 575, 751 23 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04328"},{"key":"e_1_3_1_3_2","first-page":"515","volume":"76","year":"1998","unstructured":"J. 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Adachi for calling our attention to the similarities between vertebrate mast cells and ascidian test cells and M. Liebersbach and A. Xu for technical assistance. This work was supported by NIH grants R37 AI23990 R01 CA72074 and P50 HL67674 (to S.J.G.) and by grants from the Deutsche Forschungsgemeinschaft (ME2668\/1-1 to M.M.) and the Boehringer Ingelheim Fonds (to V.L.)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1128877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T03:50:58Z","timestamp":1736481058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1128877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,28]]},"references-count":32,"journal-issue":{"issue":"5786","published-print":{"date-parts":[[2006,7,28]]}},"alternative-id":["10.1126\/science.1128877"],"URL":"https:\/\/doi.org\/10.1126\/science.1128877","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,28]]}}}