{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:58:15Z","timestamp":1790722695866,"version":"4.1.0"},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5799","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2006,10,27]]},"abstract":"<jats:p>\n                    To test the theory of a chemoautotrophic origin of life in a volcanic, hydrothermal setting, we explored mechanisms for the buildup of bio-organic compounds by carbon fixation on catalytic transition metal precipitates. We report the carbon monoxide\u2013dependent formation of carbon-fixation products, including an ordered series of \u03b1-hydroxy and \u03b1-amino acids of the general formula R-CHA-COOH (where R is H, CH\n                    <jats:sub>3<\/jats:sub>\n                    ,C\n                    <jats:sub>2<\/jats:sub>\n                    H\n                    <jats:sub>5<\/jats:sub>\n                    ,orHOCH\n                    <jats:sub>2<\/jats:sub>\n                    and A is OH or NH\n                    <jats:sub>2<\/jats:sub>\n                    ) by carbon fixation at 80\u00b0 to 120\u00b0C, catalyzed by nickel or nickel,iron precipitates with carbonyl, cyano, and methylthio ligands as carbon sources, with or without sulfido ligands. Calcium or magnesium hydroxide was added as a pH buffer. The results narrow the gap between biochemistry and volcanic geochemistry and open a new gateway for the exploration of a volcanic, hydrothermal origin of life.\n                  <\/jats:p>","DOI":"10.1126\/science.1130895","type":"journal-article","created":{"date-parts":[[2006,10,26]],"date-time":"2006-10-26T17:11:36Z","timestamp":1161882696000},"page":"630-632","source":"Crossref","is-referenced-by-count":185,"title":["\u03b1-Hydroxy and \u03b1-Amino Acids Under Possible Hadean, Volcanic Origin-of-Life Conditions"],"prefix":"10.1126","volume":"314","author":[{"given":"Claudia","family":"Huber","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry and Biochemistry, Technische Universita\u0308t Mu\u0308nchen, Lichtenbergstra\u00dfe 4, D-85747 Garching, Germany."},{"name":"Weinstra\u00dfe 8, D-80333 Mu\u0308nchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u0308nter","family":"Wa\u0308chtersha\u0308user","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Biochemistry, Technische Universita\u0308t Mu\u0308nchen, Lichtenbergstra\u00dfe 4, D-85747 Garching, Germany."},{"name":"Weinstra\u00dfe 8, D-80333 Mu\u0308nchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.52.4.452-484.1988"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(92)90022-X"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5483.1307"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1904"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5310.245"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5377.670"},{"key":"e_1_3_2_8_2","first-page":"937","volume":"363","year":"2005","unstructured":"F. 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Pardillo-Fontdevila,A. M. Wilhelm, H. Delmas, Lat. Am. Appl. Res.34, 71 (2004).","journal-title":"Lat. Am. Appl. Res."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5483.1337"},{"key":"e_1_3_2_23_2","first-page":"27","volume":"358","year":"2003","unstructured":"W. Martin, M. J. Russell, Philos. Trans. R. Soc. London Ser. B358, 27 (2003).","journal-title":"Philos. Trans. R. Soc. London Ser. B"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2004.05.007"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01808019"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/251050a0"},{"key":"e_1_3_2_27_2","first-page":"19","volume":"3","year":"1991","unstructured":"V. A. Zenkevich, G. Karpov, Volcanol. Seismol.3, 19 (1991).","journal-title":"Volcanol. Seismol."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1180\/minmag.1984.048.347.07"},{"key":"e_1_3_2_29_2","first-page":"308","year":"1989","unstructured":"E. T. Degens, Perspectives on Biogeochemistry (Springer, Berlin, 1989), p. 308.","journal-title":"Perspectives on Biogeochemistry"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01809852"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200250371"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msk014"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1659"},{"key":"e_1_3_2_34_2","unstructured":"This work was funded by Deutsche Forschungsgemeinschaft (grants WA-983\/1-4 and WA-983\/2-1 2). We thankA. Bacher for providing the laboratory facilities and for material support B. Cordes for HPLC-MS analysis C. Schwarz for technical assistance and four anonymous referees for improvements of the manuscript."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1130895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:59:48Z","timestamp":1704862788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1130895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,27]]},"references-count":33,"journal-issue":{"issue":"5799","published-print":{"date-parts":[[2006,10,27]]}},"alternative-id":["10.1126\/science.1130895"],"URL":"https:\/\/doi.org\/10.1126\/science.1130895","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,27]]}}}