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Circannual rhythm generation is seen as the product of the interaction between melatonin-regulated timer cells and adjacent prolactin-secreting cells, which together function as an intrapituitary \u201cpacemaker-slave\u201d timer system. These new insights open the way for a molecular analysis of long-term timing mechanisms.<\/jats:p>","DOI":"10.1126\/science.1132009","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T16:48:17Z","timestamp":1166719697000},"page":"1941-1944","source":"Crossref","is-referenced-by-count":232,"title":["Characterizing a Mammalian Circannual Pacemaker"],"prefix":"10.1126","volume":"314","author":[{"given":"Gerald A.","family":"Lincoln","sequence":"first","affiliation":[{"name":"Centre for Reproductive Biology, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, Scotland."},{"name":"Department of Physiology, Monash University, Melbourne, Australia."},{"name":"Department of Chronobiology, University of Groningen, Haren, Netherlands."},{"name":"School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain J.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Biology, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, Scotland."},{"name":"Department of Physiology, Monash University, Melbourne, Australia."},{"name":"Department of Chronobiology, University of Groningen, Haren, Netherlands."},{"name":"School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roelof A.","family":"Hut","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Biology, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, Scotland."},{"name":"Department of Physiology, Monash University, Melbourne, Australia."},{"name":"Department of Chronobiology, University of Groningen, Haren, Netherlands."},{"name":"School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Hazlerigg","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Biology, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, Scotland."},{"name":"Department of Physiology, Monash University, Melbourne, Australia."},{"name":"Department of Chronobiology, University of Groningen, Haren, Netherlands."},{"name":"School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","unstructured":"E. 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Endocrinol."},{"key":"e_1_3_1_32_2","unstructured":"We dedicate this scientific contribution to the late Norah Anderson who devoted a career to the Soay Sheep Research Programme and cared for the animals in the current study. We thank M. Thompson I. Swanston and I. Cooper for expert technical help T. Pinner for the art work and J. Johnston for constructive comments on the manuscript. The U.K. Medical Research Council provided the long-term funding."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1132009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T05:01:24Z","timestamp":1704862884000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1132009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,22]]},"references-count":31,"journal-issue":{"issue":"5807","published-print":{"date-parts":[[2006,12,22]]}},"alternative-id":["10.1126\/science.1132009"],"URL":"https:\/\/doi.org\/10.1126\/science.1132009","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1064743.517659","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,22]]}}}