{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:01:25Z","timestamp":1791162085645,"version":"4.1.0"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5809","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,1,12]]},"abstract":"<jats:p>\n                    We describe the genome sequence of the protist\n                    <jats:italic>Trichomonas vaginalis<\/jats:italic>\n                    , a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the \u223c160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.\n                  <\/jats:p>","DOI":"10.1126\/science.1132894","type":"journal-article","created":{"date-parts":[[2007,1,12]],"date-time":"2007-01-12T07:48:04Z","timestamp":1168588084000},"page":"207-212","source":"Crossref","is-referenced-by-count":726,"title":["Draft Genome Sequence of the Sexually Transmitted Pathogen\n                    <i>Trichomonas vaginalis<\/i>"],"prefix":"10.1126","volume":"315","author":[{"given":"Jane M.","family":"Carlton","sequence":"first","affiliation":[{"name":"Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA."},{"name":"Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK."},{"name":"Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA."},{"name":"Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK."},{"name":"Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Hirt","sequence":"additional","affiliation":[{"name":"Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA."},{"name":"Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK."},{"name":"Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA."},{"name":"Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK."},{"name":"Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana C.","family":"Silva","sequence":"additional","affiliation":[{"name":"Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA."},{"name":"Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK."},{"name":"Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA."},{"name":"Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK."},{"name":"Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur L.","family":"Delcher","sequence":"additional","affiliation":[{"name":"Institute for Genomic Research, 9712 Medical 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The Burroughs Wellcome Fund and the Ellison Medical Foundation provided funds for Trichomonas community meetings during the genome project. The Chang Gung T. vaginalis Systems Biology Project was supported by grants (SMRPD33002 and SMRPG33115) from Chang Gung Memorial Hospital and Taiwan Biotech Company Limited. This whole genome shotgun project has been deposited at DNA Data Bank of Japan\/European Molecular Biology Laboratory\/GenBank under the project accession AAHC00000000. The version described here is the first version AAHC01000000."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1132894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:39:02Z","timestamp":1704861542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1132894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,12]]},"references-count":43,"journal-issue":{"issue":"5809","published-print":{"date-parts":[[2007,1,12]]}},"alternative-id":["10.1126\/science.1132894"],"URL":"https:\/\/doi.org\/10.1126\/science.1132894","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718395373.793514021","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,12]]}}}