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In vivo administration of an oxytocin receptor antagonist before delivery prevented the switch of GABA actions in fetal neurons and aggravated the severity of anoxic episodes. Thus, maternal oxytocin inhibits fetal neurons and increases their resistance to insults during delivery.<\/jats:p>","DOI":"10.1126\/science.1133212","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T19:55:55Z","timestamp":1166126155000},"page":"1788-1792","source":"Crossref","is-referenced-by-count":449,"title":["Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery"],"prefix":"10.1126","volume":"314","author":[{"given":"Roman","family":"Tyzio","sequence":"first","affiliation":[{"name":"Institut de Neurobiologie de la Me\u0301diterrane\u0301e, INSERM U29, Universite\u0301 de la Me\u0301diterrane\u0301e, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France."},{"name":"Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Cossart","sequence":"additional","affiliation":[{"name":"Institut de Neurobiologie de la Me\u0301diterrane\u0301e, INSERM U29, Universite\u0301 de la Me\u0301diterrane\u0301e, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France."},{"name":"Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilgam","family":"Khalilov","sequence":"additional","affiliation":[{"name":"Institut de Neurobiologie de la Me\u0301diterrane\u0301e, INSERM U29, Universite\u0301 de la Me\u0301diterrane\u0301e, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France."},{"name":"Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat","family":"Minlebaev","sequence":"additional","affiliation":[{"name":"Institut de Neurobiologie de la Me\u0301diterrane\u0301e, INSERM U29, Universite\u0301 de la Me\u0301diterrane\u0301e, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France."},{"name":"Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.","family":"Hu\u0308bner","sequence":"additional","affiliation":[{"name":"Institut de Neurobiologie de la Me\u0301diterrane\u0301e, INSERM U29, Universite\u0301 de la Me\u0301diterrane\u0301e, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France."},{"name":"Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Represa","sequence":"additional","affiliation":[{"name":"Institut de Neurobiologie de la Me\u0301diterrane\u0301e, INSERM U29, Universite\u0301 de la Me\u0301diterrane\u0301e, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France."},{"name":"Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehezkel","family":"Ben-Ari","sequence":"additional","affiliation":[{"name":"Institut de Neurobiologie de la Me\u0301diterrane\u0301e, INSERM U29, Universite\u0301 de la Me\u0301diterrane\u0301e, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France."},{"name":"Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rustem","family":"Khazipov","sequence":"additional","affiliation":[{"name":"Institut de Neurobiologie de la Me\u0301diterrane\u0301e, INSERM U29, Universite\u0301 de la Me\u0301diterrane\u0301e, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France."},{"name":"Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","unstructured":"J. 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Malek, E. Blann, D. R. Mattison, J. Matern. Fetal Med.5, 245 (1996).","journal-title":"J. Matern. Fetal Med."},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-002-0933-7"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.061200"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.062471"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1301"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200010)48:4<632::AID-ANA10>3.0.CO;2-3"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1431"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.10.025"},{"key":"e_1_3_1_35_2","unstructured":"We thank I. Jorquera I. Chudotvorova D. Diabira and C. Pellegrino for technical assistance; K. Krnjevic M. Milh I. Medyna J. L. Gaiarsa A. Ivanov and C. Hammond for helpful comments on the manuscript; and Sanofi-Synthelabs for the gift of SSR126768A. This work was supported by INSERM Fondation pour la Recherche M\u00e9dicale L`Agence Nationale de la Recherche Federation pour la Recherche sur le Cerveau and Rotary International Conseil r\u00e9gional Provence-Alpes-C\u00f4te d`Azur and European Community grant LSHB-CT-2004-503467."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1133212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:49:10Z","timestamp":1704862150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1133212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,15]]},"references-count":34,"journal-issue":{"issue":"5806","published-print":{"date-parts":[[2006,12,15]]}},"alternative-id":["10.1126\/science.1133212"],"URL":"https:\/\/doi.org\/10.1126\/science.1133212","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1057873.559524","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1057873.509806","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1057873.534778","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,15]]}}}