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Here, I review several recent studies on four diseases that show the benefits of different methodologies: measles (patch models), foot-and-mouth disease (distance-transmission models), pandemic influenza (multigroup models), and smallpox (network models). This review highlights the importance of the household in spatial studies of human diseases, such as smallpox and influenza. It also demonstrates the need to develop a simple model of household demographics, so that these large-scale models can be extended to the investigation of long\u2013time scale human pathogens, such as tuberculosis and HIV.<\/jats:p>","DOI":"10.1126\/science.1134695","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T16:54:28Z","timestamp":1180630468000},"page":"1298-1301","source":"Crossref","is-referenced-by-count":520,"title":["Large-Scale Spatial-Transmission Models of Infectious Disease"],"prefix":"10.1126","volume":"316","author":[{"given":"Steven","family":"Riley","sequence":"first","affiliation":[{"name":"Department of Community Medicine and School of Public Health, Faculty of Medicine, University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.1073\/pnas.0408290102","volume":"102","year":"2005","unstructured":"D. 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