{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:22:05Z","timestamp":1792182125102,"version":"4.4.0"},"reference-count":15,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5811","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,1,26]]},"abstract":"<jats:p>\n                    Adult stem cells often divide asymmetrically to produce one self-renewed stem cell and one differentiating cell, thus maintaining both populations. The asymmetric outcome of stem cell divisions can be specified by an oriented spindle and local self-renewal signals from the stem cell niche. Here we show that developmentally programmed asymmetric behavior and inheritance of mother and daughter centrosomes underlies the stereotyped spindle orientation and asymmetric outcome of stem cell divisions in the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    male germ line. The mother centrosome remains anchored near the niche while the daughter centrosome migrates to the opposite side of the cell before spindle formation.\n                  <\/jats:p>","DOI":"10.1126\/science.1134910","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T16:27:07Z","timestamp":1169742427000},"page":"518-521","source":"Crossref","is-referenced-by-count":522,"title":["Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell Division"],"prefix":"10.1126","volume":"315","author":[{"given":"Yukiko M.","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305\u20135329, USA."},{"name":"Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA."},{"name":"Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305\u20135329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Mahowald","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305\u20135329, USA."},{"name":"Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA."},{"name":"Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305\u20135329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R.","family":"Perlin","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305\u20135329, USA."},{"name":"Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA."},{"name":"Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305\u20135329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret T.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305\u20135329, USA."},{"name":"Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA."},{"name":"Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305\u20135329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04956"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/35102160"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1427"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066707"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066700"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087795"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200402130"},{"key":"e_1_3_2_9_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/154.1.273"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00017-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80393-5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.13.2829"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.22.6359"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.2.317"},{"key":"e_1_3_2_16_2","unstructured":"We thank the Bloomington Stock Center the Developmental Studies Hybridoma Bank and R. Lehmann for reagents; the Stanford Cell Science Imaging Facility for assistance in microscopy; Fuller lab members for comments; the Jose Carreras International Leukemia Foundation for a fellowship to Y.M.Y.; and NIH for grant P01 DK53074 to M.T.F."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1134910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:59:54Z","timestamp":1704862794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1134910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,26]]},"references-count":15,"journal-issue":{"issue":"5811","published-print":{"date-parts":[[2007,1,26]]}},"alternative-id":["10.1126\/science.1134910"],"URL":"https:\/\/doi.org\/10.1126\/science.1134910","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1064786.524672","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1064786.517707","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1064786.523980","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1064786.516780","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1064786.521677","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,26]]}}}