{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:35:03Z","timestamp":1791160503722,"version":"4.1.0"},"reference-count":23,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5811","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,1,26]]},"abstract":"<jats:p>\n                    Primary pneumonic plague is transmitted easily, progresses rapidly, and causes high mortality, but the mechanisms by which\n                    <jats:italic>Yersinia pestis<\/jats:italic>\n                    overwhelms the lungs are largely unknown. We show that the plasminogen activator Pla is essential for\n                    <jats:italic>Y. pestis<\/jats:italic>\n                    to cause primary pneumonic plague but is less important for dissemination during pneumonic plague than during bubonic plague. Experiments manipulating its temporal expression showed that Pla allows\n                    <jats:italic>Y. pestis<\/jats:italic>\n                    to replicate rapidly in the airways, causing a lethal fulminant pneumonia; if unexpressed, inflammation is aborted, and lung repair is activated. Inhibition of Pla expression prolonged the survival of animals with the disease, offering a therapeutic option to extend the period during which antibiotics are effective.\n                  <\/jats:p>","DOI":"10.1126\/science.1137195","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T16:27:07Z","timestamp":1169742427000},"page":"509-513","source":"Crossref","is-referenced-by-count":235,"title":["A Plasminogen-Activating Protease Specifically Controls the Development of Primary Pneumonic Plague"],"prefix":"10.1126","volume":"315","author":[{"given":"Wyndham W.","family":"Lathem","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.1.35"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1001\/jama.283.17.2281","volume":"283","year":"2000","unstructured":"T. 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This work was supported by NIH grant U54 AI057160 to the Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research (MRCE) and by NIH grant AI53298. The DDRCC is supported by NIH grant DK52574. W.W.L. was supported by the Clinical\/Translational Fellowship Program of the MRCE the W.M. Keck Foundation and the NIH National Research Service Award (NRSA) F32 AI069688-01. P.A.P. was supported by the NIH Institutional NRSA T32 GM07067 to the Washington University School of Medicine."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1137195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:58:33Z","timestamp":1704862713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1137195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,26]]},"references-count":23,"journal-issue":{"issue":"5811","published-print":{"date-parts":[[2007,1,26]]}},"alternative-id":["10.1126\/science.1137195"],"URL":"https:\/\/doi.org\/10.1126\/science.1137195","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1066688.559014","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1066688.519597","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,26]]}}}