{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:49:01Z","timestamp":1792205341917,"version":"4.4.0"},"reference-count":17,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5815","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,2,23]]},"abstract":"<jats:p>\n                    Rett syndrome is an autism spectrum disorder caused by mosaic expression of mutant copies of the X-linked\n                    <jats:italic>MECP2<\/jats:italic>\n                    gene in neurons. However, neurons do not die, which suggests that this is not a neurodegenerative disorder. An important question for future therapeutic approaches to this and related disorders concerns phenotypic reversibility. Can viable but defective neurons be repaired, or is the damage done during development without normal MeCP2 irrevocable? Using a mouse model, we demonstrate robust phenotypic reversal, as activation of MeCP2 expression leads to striking loss of advanced neurological symptoms in both immature and mature adult animals.\n                  <\/jats:p>","DOI":"10.1126\/science.1138389","type":"journal-article","created":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T21:05:46Z","timestamp":1170968746000},"page":"1143-1147","source":"Crossref","is-referenced-by-count":1101,"title":["Reversal of Neurological Defects in a Mouse Model of Rett Syndrome"],"prefix":"10.1126","volume":"315","author":[{"given":"Jacky","family":"Guy","sequence":"first","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, Edinburgh University, The King's Buildings, Edinburgh EH9 3JR, UK."},{"name":"Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gan","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, Edinburgh University, The King's Buildings, Edinburgh EH9 3JR, UK."},{"name":"Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Selfridge","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, Edinburgh University, The King's Buildings, Edinburgh EH9 3JR, UK."},{"name":"Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Cobb","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, Edinburgh University, The King's Buildings, Edinburgh EH9 3JR, UK."},{"name":"Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Bird","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, Edinburgh University, The King's Buildings, Edinburgh EH9 3JR, UK."},{"name":"Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858403260995"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199503000-00006"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.07.006"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/85906"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/85899"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401626101"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.3.e10"},{"key":"e_1_3_1_10_2","unstructured":"Materials and Methods are available as supporting material on Science Online."},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0597"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh282"},{"issue":"2","key":"e_1_3_1_13_2","first-page":"R221","volume":"12","year":"2003","unstructured":"S. Kriaucionis, A. Bird, Hum. Mol. Genet.12 (spec. issue 2), R221 (2003).","journal-title":"Hum. Mol. Genet."},{"key":"e_1_3_1_14_2","first-page":"217","volume":"21","year":"2005","unstructured":"Y. Asaka, D. G. Jugloff, L. Zhang, J. H. Eubanks, R. M. Fitzsimonds, Neurobiol. Dis.21, 217 (2005).","journal-title":"Neurobiol. Dis."},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2623-05.2006"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81887-5"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90610-O"},{"key":"e_1_3_1_18_2","unstructured":"We are grateful to A. McClure and D. DeSousa for excellent technical assistance; to S. Zeitlin and J. Pevsner for reagents; and to D. Kleinjan I. Vida and R. Morris for comments on the manuscript. The work was funded by the Wellcome Trust the Rett Syndrome Research Foundation (USA) and Rett Syndrome UK\/Jeans for Genes."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1138389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:16:56Z","timestamp":1704856616000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1138389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,23]]},"references-count":17,"journal-issue":{"issue":"5815","published-print":{"date-parts":[[2007,2,23]]}},"alternative-id":["10.1126\/science.1138389"],"URL":"https:\/\/doi.org\/10.1126\/science.1138389","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1066718.527638","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1066718.524687","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1066718.519043","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1066718.519633","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,23]]}}}