{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:49:05Z","timestamp":1791607745207,"version":"4.3.4"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5832","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,6,22]]},"abstract":"<jats:p>\n                    We present a draft sequence of the genome of\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    , the primary vector for yellow fever and dengue fever, which at \u223c1376 million base pairs is about 5 times the size of the genome of the malaria vector\n                    <jats:italic>Anopheles gambiae<\/jats:italic>\n                    . Nearly 50% of the\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    genome consists of transposable elements. These contribute to a factor of \u223c4 to 6 increase in average gene length and in sizes of intergenic regions relative to\n                    <jats:italic>An. gambiae<\/jats:italic>\n                    and\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    . Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of \u223c2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to\n                    <jats:italic>An. gambiae<\/jats:italic>\n                    suggests that members of these protein families underpin some of the biological differences between the two mosquito species.\n                  <\/jats:p>","DOI":"10.1126\/science.1138878","type":"journal-article","created":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T13:13:09Z","timestamp":1179493989000},"page":"1718-1723","source":"Crossref","is-referenced-by-count":981,"title":["Genome Sequence of\n                    <i>Aedes aegypti<\/i>\n                    , a Major Arbovirus Vector"],"prefix":"10.1126","volume":"316","author":[{"given":"Vishvanath","family":"Nene","sequence":"first","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK."},{"name":"Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02141, USA."},{"name":"Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA."},{"name":"Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Wortman","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK."},{"name":"Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02141, USA."},{"name":"Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA."},{"name":"Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lawson","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK."},{"name":"Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02141, USA."},{"name":"Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA."},{"name":"Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Haas","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, 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(Jake)","family":"Tu","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK."},{"name":"Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02141, USA."},{"name":"Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA."},{"name":"Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Loftus","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK."},{"name":"Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 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