{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:52:16Z","timestamp":1793933536248,"version":"4.8.0"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5824","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,4,27]]},"abstract":"<jats:p>\n                    The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of \u03b1\u2013myosin heavy chain (\u03b1MHC) and up-regulation of \u03b2MHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the \u03b1\n                    <jats:italic>MHC<\/jats:italic>\n                    gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of \u03b2\n                    <jats:italic>MHC<\/jats:italic>\n                    in response to stress and hypothyroidism. Thus, the \u03b1\n                    <jats:italic>MHC<\/jats:italic>\n                    gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208.\n                  <\/jats:p>","DOI":"10.1126\/science.1139089","type":"journal-article","created":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T20:33:01Z","timestamp":1174595581000},"page":"575-579","source":"Crossref","is-referenced-by-count":1411,"title":["Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA"],"prefix":"10.1126","volume":"316","author":[{"given":"Eva","family":"van Rooij","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390\u20139148, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian B.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390\u20139148, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390\u20139148, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390\u20139148, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390\u20139148, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric N.","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390\u20139148, USA."},{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390\u20139148, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.12.1.417"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20000915)50:6<522::AID-JEMT9>3.0.CO;2-U"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.044"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.62.1.321"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11093"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119770"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.4.386"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119776"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402039"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24144"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.09.009"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1840"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602266103"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2005.12.005"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00428-8"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03817"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1725"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608791103"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54273-3"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01931494"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118992"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.24.2863"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81573-1"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.6.7514"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1536"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00355-6"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608845103"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345522"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-925404"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.71.4.831"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(00)00203-3"},{"issue":"1","key":"e_1_3_1_34_2","first-page":"S57","volume":"53","year":"2004","unstructured":"A. Vadaszova, G. Zacharova, K. Machacova, I. Jirmanova, T. Soukup, Physiol. Res.53, (suppl. 1), S57 (2004).","journal-title":"Physiol. Res."},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.02.034"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.08.008"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.10.7963-3"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend.15.12.0735"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/hh1901.096706"},{"key":"e_1_3_1_40_2","unstructured":"This work was supported by grants from the NIH and the Donald W. Reynolds Cardiovascular Clinical Research Center to E.N.O. We thank C. Plato at Gilead Colorado (Westminster CO) for providing human and rat RNA samples; M. Arnold for advice; and J. Shelton J. McAnally and C. Nolen for technical assistance."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1139089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:40:52Z","timestamp":1704858052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1139089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,27]]},"references-count":39,"journal-issue":{"issue":"5824","published-print":{"date-parts":[[2007,4,27]]}},"alternative-id":["10.1126\/science.1139089"],"URL":"https:\/\/doi.org\/10.1126\/science.1139089","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1071988.535994","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1071988.524951","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1071988.535777","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,27]]}}}