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This modulation was found to alter the localization of lymphocytes and dendritic cells within responding lymphoid tissues. As a consequence, priming of T cell responses to a second distinct pathogen after chemokine modulation became impaired. We propose that this transient chemokine modulation may help orchestrate local cellularity, thus minimizing competition for space and resources in activated lymphoid tissues.<\/jats:p>","DOI":"10.1126\/science.1144830","type":"journal-article","created":{"date-parts":[[2007,8,2]],"date-time":"2007-08-02T17:08:01Z","timestamp":1186074481000},"page":"670-674","source":"Crossref","is-referenced-by-count":234,"title":["Regulation of Homeostatic Chemokine Expression and Cell Trafficking During Immune Responses"],"prefix":"10.1126","volume":"317","author":[{"given":"Scott N.","family":"Mueller","sequence":"first","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"Department of Medicine, Division of Rheumatology, University of California, San Francisco, CA 94143, USA."},{"name":"Howard Hughes Medical Institute and Department of Medicine and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA."},{"name":"Cytos Biotechnology AG, Wagisstrasse 25, 8952 Schlieren, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline A.","family":"Hosiawa-Meagher","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"Department of Medicine, Division of Rheumatology, University of California, San Francisco, CA 94143, USA."},{"name":"Howard Hughes Medical Institute and Department of Medicine and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA."},{"name":"Cytos Biotechnology AG, Wagisstrasse 25, 8952 Schlieren, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogumila T.","family":"Konieczny","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology 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Saeki, A. M. Moore, M. J. Brown, S. T. Hwang, J. Immunol.162, 2472 (1999).","journal-title":"J. Immunol."},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.3.451"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1300"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04606"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.5.2973"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061706"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.10.011"},{"key":"e_1_3_1_21_2","unstructured":"We thank J. Browning for murine LT\u03b2R-Ig a fusion protein of mouse LT\u03b2R and human immunoglobulin G (hIgG). This work was supported by grant AI30048 from the NIH to R.A.; S.M. was funded by a C. J. Martin postdoctoral fellowship from the National Health and Medical Research Council of Australia. M.M. was supported by research awards from the Arthritis Foundation the Rosalind Russell Medical Research Center for Arthritis at UCSF and the Sandler Family Supporting Foundation."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1144830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:03:00Z","timestamp":1704855780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1144830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,3]]},"references-count":20,"journal-issue":{"issue":"5838","published-print":{"date-parts":[[2007,8,3]]}},"alternative-id":["10.1126\/science.1144830"],"URL":"https:\/\/doi.org\/10.1126\/science.1144830","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1089189.542388","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,3]]}}}