{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:17:11Z","timestamp":1791674231203,"version":"4.3.4"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5845","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,9,21]]},"abstract":"<jats:p>\n                    Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the \u223c90 megabase (Mb) genome of the human filarial parasite\n                    <jats:italic>Brugia malayi<\/jats:italic>\n                    and predict \u223c11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    revealed that, despite these genes having maintained little conservation of local synteny during \u223c350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of\n                    <jats:italic>B. malayi<\/jats:italic>\n                    to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    endosymbiont. These findings offer a foundation for rational drug design.\n                  <\/jats:p>","DOI":"10.1126\/science.1145406","type":"journal-article","created":{"date-parts":[[2007,9,20]],"date-time":"2007-09-20T17:24:10Z","timestamp":1190309050000},"page":"1756-1760","source":"Crossref","is-referenced-by-count":538,"title":["Draft Genome of the Filarial Nematode Parasite\n                    <i>Brugia malayi<\/i>"],"prefix":"10.1126","volume":"317","author":[{"given":"Elodie","family":"Ghedin","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA."},{"name":"The Institute for Genomic Research (TIGR) and the J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"Division of Cell and Molecular Biology, Biochemistry Building, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK."},{"name":"School of Life Sciences Research, University of Dundee, Dow Street, Dundee, DD1 5EH, UK."},{"name":"Division of Parasitology, New England BioLabs, Inc., 240 County Road, Ipswich, MA 01938, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA."},{"name":"The Institute for Genomic Research (TIGR) and the J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"Division of Cell and Molecular Biology, Biochemistry Building, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK."},{"name":"School of Life Sciences Research, University of Dundee, Dow Street, Dundee, DD1 5EH, UK."},{"name":"Division of Parasitology, New England BioLabs, Inc., 240 County Road, Ipswich, MA 01938, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Spiro","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA."},{"name":"The Institute for Genomic Research (TIGR) and the J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"Division of Cell and Molecular Biology, Biochemistry Building, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK."},{"name":"School of Life Sciences Research, University of Dundee, Dow Street, Dundee, DD1 5EH, UK."},{"name":"Division of Parasitology, New England BioLabs, Inc., 240 County Road, Ipswich, MA 01938, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Caler","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA."},{"name":"The Institute for Genomic Research (TIGR) and the J. 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We would like to acknowledge our colleagues in the Filarial Genome Consortium and the filarial research community for their continued support and encouragement. The Filarial Genome Consortium was initiated by grants from the United Nations Special Programme for Research and Training in Tropical Diseases (TDR) which is cosponsored by the U.N. Children's Fund (UNICEF) U.N. Development Programme (UNDP) World Bank and World Health Organization (WHO) (T23\/79\/152 to A.L.S.; T23\/79\/153 to B.S.; and T23\/79\/157 to S.A.W.). This whole-genome shotgun project has been deposited at the DNA Databank of Japan (DDBJ) European Molecular Biology Laboratory (EMBL) and GenBank under the project accession AAQA00000000. The version described in this paper is the first version AAQA01000000. The data are also available in WormBase release WS175."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1145406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T20:16:26Z","timestamp":1708200986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1145406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,21]]},"references-count":30,"journal-issue":{"issue":"5845","published-print":{"date-parts":[[2007,9,21]]}},"alternative-id":["10.1126\/science.1145406"],"URL":"https:\/\/doi.org\/10.1126\/science.1145406","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1091963.545307","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,21]]}}}