{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T23:30:33Z","timestamp":1792971033902,"version":"4.5.0"},"reference-count":19,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5835","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,7,13]]},"abstract":"<jats:p>\n                    The cytokine transforming growth factor\u2013\u03b2 (TGF-\u03b2) converts nai\u0308ve T cells into regulatory T (Treg) cells that prevent autoimmunity. However, in the presence of interleukin-6 (IL-6), TGF-\u03b2 has also been found to promote the differentiation of nai\u0308ve T lymphocytes into proinflammatory IL-17 cytokine-producing T helper 17 (T\n                    <jats:sub>H<\/jats:sub>\n                    17) cells, which promote autoimmunity and inflammation. This raises the question of how TGF-\u03b2 can generate such distinct outcomes. We identified the vitamin A metabolite retinoic acid as a key regulator of TGF-\u03b2\u2013dependent immune responses, capable of inhibiting the IL-6\u2013driven induction of proinflammatory T\n                    <jats:sub>H<\/jats:sub>\n                    17 cells and promoting anti-inflammatory Treg cell differentiation. These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity.\n                  <\/jats:p>","DOI":"10.1126\/science.1145697","type":"journal-article","created":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T20:59:30Z","timestamp":1181854770000},"page":"256-260","source":"Crossref","is-referenced-by-count":1787,"title":["Reciprocal T\n                    <sub>H<\/sub>\n                    17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid"],"prefix":"10.1126","volume":"317","author":[{"given":"Daniel","family":"Mucida","sequence":"first","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunji","family":"Park","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisen","family":"Kim","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Turovskaya","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Scott","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Kronenberg","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Cheroutre","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.10.002"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.01.001"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04754"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141634"},{"key":"e_1_3_1_7_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.011"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.22.15360"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.035"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni904"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni909"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24487"},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.4049\/jimmunol.159.8.3748","volume":"159","year":"1997","unstructured":"G. A. Hadley, S. T. Bartlett, C. S. Via, E. A. Rostapshova, S. Moainie, J. Immunol.159, 3748 (1997).","journal-title":"J. Immunol."},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00423.x"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4022"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.02.009"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.5.1003"},{"key":"e_1_3_1_20_2","unstructured":"We thank M. Steinberg Y. Kinjo and E. Tupin for helpful discussions; X. Zhang for providing the LE135 inhibitor; Y. Wang-Zhu for providing C57BL\/6 mice; C. Lena for help in intraepithelial lymphocyte preparations; S. Feau and Y. Huang for help with Listeria infection; and M. Cheroutre for her contribution. This work was supported by NIH grant RO1 AI050265-06 and The Crohn's and Colitis Foundation of America fellowship (Y.P.)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1145697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:40:27Z","timestamp":1704861627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1145697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,13]]},"references-count":19,"journal-issue":{"issue":"5835","published-print":{"date-parts":[[2007,7,13]]}},"alternative-id":["10.1126\/science.1145697"],"URL":"https:\/\/doi.org\/10.1126\/science.1145697","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1087584.542327","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1087584.563019","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1087584.542744","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1087584.542976","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1087584.540653","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1087584.542116","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,13]]}}}