{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:28:44Z","timestamp":1791217724297,"version":"4.1.0"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5847","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,10,5]]},"abstract":"<jats:p>\n                    Mounting a protective immune response is critically dependent on the orchestrated movement of cells within lymphoid organs. We report here the visualization, using major histocompatability complex class I tetramers, of the CD8-positive (CD8) T cell response in the spleens of mice to\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    infection. A multistage pathway was revealed that included initial activation at the borders of the B and T cell zones followed by cluster formation with antigenpresenting cells leading to CD8 T cell exit to the red pulp via bridging channels. Strikingly, many memory CD8 T cells localized to the B cell zones and, when challenged, underwent rapid migration to the T cell zones where proliferation occurred, followed by egress via bridging channels in parallel with the primary response. Thus, the ability to track endogenous immune responses has uncovered both distinct and overlapping mechanisms and anatomical locations driving primary and secondary immune responses.\n                  <\/jats:p>","DOI":"10.1126\/science.1146291","type":"journal-article","created":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T16:39:21Z","timestamp":1191515961000},"page":"116-120","source":"Crossref","is-referenced-by-count":101,"title":["In Situ Imaging of the Endogenous CD8 T Cell Response to Infection"],"prefix":"10.1126","volume":"318","author":[{"given":"Kamal M.","family":"Khanna","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Connecticut, Farmington, CT 06030, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery T.","family":"McNamara","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Connecticut, Farmington, CT 06030, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Lefranc\u0327ois","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Connecticut, Farmington, CT 06030, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070051"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni928"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02238"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610019104"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4049\/jimmunol.165.2.613","volume":"165","year":"2000","unstructured":"P. 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Immunol."},{"key":"e_1_3_1_20_2","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.4049\/jimmunol.173.5.3013","volume":"173","year":"2004","unstructured":"H. Unsoeld, D. Voehringer, S. Krautwald, H. Pircher, J. Immunol.173, 3013 (2004).","journal-title":"J. Immunol."},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/87730"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/87720"},{"key":"e_1_3_1_23_2","unstructured":"K.M.K is a Damon Runyon Fellow supported by the Damon Runyon Cancer Research Foundation (DRG-1886-05) and by NIH grants AI41576 and AI56172 (LL). We gratefully acknowledge the assistance of A. Cowan and the Center for Cell Analysis and Modeling."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1146291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:50:57Z","timestamp":1704855057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1146291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,5]]},"references-count":22,"journal-issue":{"issue":"5847","published-print":{"date-parts":[[2007,10,5]]}},"alternative-id":["10.1126\/science.1146291"],"URL":"https:\/\/doi.org\/10.1126\/science.1146291","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1094994.549970","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1094994.550006","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,5]]}}}