{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:38:30Z","timestamp":1792618710213,"version":"4.5.0"},"reference-count":20,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5847","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,10,5]]},"abstract":"<jats:p>In plants, the mobile signal for systemic acquired resistance (SAR), an organism-wide state of enhanced defense to subsequent infections, has been elusive. By stimulating immune responses in mosaic tobacco plants created by grafting different genetic backgrounds, we showed that the methyl salicylate (MeSA) esterase activity of salicylic acid\u2013binding protein 2 (SABP2), which converts MeSA into salicylic acid (SA), is required for SAR signal perception in systemic tissue, the tissue that does not receive the primary (initial) infection. Moreover, in plants expressing mutant SABP2 with unregulated MeSA esterase activity in SAR signal\u2013generating, primary infected leaves, SAR was compromised and the associated increase in MeSA levels was suppressed in primary infected leaves, their phloem exudates, and systemic leaves. SAR was also blocked when SA methyl transferase (which converts SA to MeSA) was silenced in primary infected leaves, and MeSA treatment of lower leaves induced SAR in upper untreated leaves. Therefore, we conclude that MeSA is a SAR signal in tobacco.<\/jats:p>","DOI":"10.1126\/science.1147113","type":"journal-article","created":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T16:39:21Z","timestamp":1191515961000},"page":"113-116","source":"Crossref","is-referenced-by-count":905,"title":["Methyl Salicylate Is a Critical Mobile Signal for Plant Systemic Acquired Resistance"],"prefix":"10.1126","volume":"318","author":[{"given":"Sang-Wook","family":"Park","sequence":"first","affiliation":[{"name":"Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evans","family":"Kaimoyo","sequence":"additional","affiliation":[{"name":"Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhirendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Mosher","sequence":"additional","affiliation":[{"name":"Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Klessig","sequence":"additional","affiliation":[{"name":"Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/07352689991309397"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.phyto.42.040803.140421"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1094\/Phyto-69-753"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2307\/3870006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.1996.10020281.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266079"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182427699"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.113.4.1319"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307162100"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409227102"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.116.1.387"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.116.2.599"},{"key":"e_1_3_2_14_2","unstructured":"See supporting material on Science Online."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2005.02645.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.2000.00868.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/385718a0"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00962"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.016907"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605423104"},{"key":"e_1_3_2_21_2","unstructured":"We thank L. Tong for advice regarding SABP2 mutational analysis A. Kessler for advice on GC\/MS analyses N.-H. Chua for estradiol-inducible pER8 vector DNA2.0 Inc. for synthesizing syn2 SABP2 J. Ryals for the transgenic NahG-10 tobacco line encoding a salicylate hydroxylase ( 4 ) and D. Dempsey for critical comment on the manuscript. Supported by NSF grants IOB-0525360 and DBI-0500550 (D.F.K.)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1147113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:52:08Z","timestamp":1704855128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1147113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,5]]},"references-count":20,"journal-issue":{"issue":"5847","published-print":{"date-parts":[[2007,10,5]]}},"alternative-id":["10.1126\/science.1147113"],"URL":"https:\/\/doi.org\/10.1126\/science.1147113","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1091366.545803","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,5]]}}}