{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:26:00Z","timestamp":1791919560833,"version":"4.3.4"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5861","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2008,1,18]]},"abstract":"<jats:p>\n                    Dietary vitamin A deficiency causes eye disease in 40 million children each year and places 140 to 250 million at risk for health disorders. Many children in sub-Saharan Africa subsist on maize-based diets. Maize displays considerable natural variation for carotenoid composition, including vitamin A precursors \u03b1-carotene, \u03b2-carotene, and \u03b2-cryptoxanthin. Through association analysis, linkage mapping, expression analysis, and mutagenesis, we show that variation at the\n                    <jats:italic>lycopene epsilon cyclase<\/jats:italic>\n                    (\n                    <jats:italic>lcyE<\/jats:italic>\n                    ) locus alters flux down \u03b1-carotene versus \u03b2-carotene branches of the carotenoid pathway. Four natural\n                    <jats:italic>lcyE<\/jats:italic>\n                    polymorphisms explained 58% of the variation in these two branches and a threefold difference in provitamin A compounds. Selection of favorable\n                    <jats:italic>lcyE<\/jats:italic>\n                    alleles with inexpensive molecular markers will now enable developing-country breeders to more effectively produce maize grain with higher provitamin A levels.\n                  <\/jats:p>","DOI":"10.1126\/science.1150255","type":"journal-article","created":{"date-parts":[[2008,1,17]],"date-time":"2008-01-17T19:36:13Z","timestamp":1200598573000},"page":"330-333","source":"Crossref","is-referenced-by-count":674,"title":["Natural Genetic Variation in\n                    <i>Lycopene Epsilon Cyclase<\/i>\n                    Tapped for Maize Biofortification"],"prefix":"10.1126","volume":"319","author":[{"given":"Carlos E.","family":"Harjes","sequence":"first","affiliation":[{"name":"Institute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USA."},{"name":"Department of Crop Sciences, University of Illinois, Urbana, IL 61801, USA."},{"name":"Boyce Thompson Institute, Ithaca, NY 14853, USA."},{"name":"DuPont Crop Genetics Research, Wilmington, DE 19880, USA."},{"name":"Department of Biology and Marine Biology, University of North Carolina, Wilmington, NC 28403, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbert R.","family":"Rocheford","sequence":"additional","affiliation":[{"name":"Institute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USA."},{"name":"Department of Crop Sciences, University of Illinois, Urbana, IL 61801, USA."},{"name":"Boyce Thompson Institute, Ithaca, NY 14853, USA."},{"name":"DuPont Crop Genetics Research, Wilmington, DE 19880, USA."},{"name":"Department of Biology and Marine Biology, University of North Carolina, Wilmington, NC 28403, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USA."},{"name":"Department of Crop Sciences, University 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U.S. Agency for International Development (to T.R.R.) HarvestPlus (to T.R.R.) NIH (S06-GM08225 to E.T.W.) Professional Staff Congress\u2014CUNY research award (to E.T.W.) New York State (to E.T.W.) NSF DBI-0604923 (to T.R.R) TRIAD Foundation (L.B. and T.P.B.) U.S. Department of Agriculture (USDA) Cooperative State Research Education and Extension Service (CSREES) National Research Initiative grant 2003-00745 (to A.E.S.) and USDA\u2014Agricultural Research Service (to E.S.B.). Mention of trade names or commercial products in this publication is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the USDA."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1150255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:06:23Z","timestamp":1704855983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1150255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,18]]},"references-count":30,"journal-issue":{"issue":"5861","published-print":{"date-parts":[[2008,1,18]]}},"alternative-id":["10.1126\/science.1150255"],"URL":"https:\/\/doi.org\/10.1126\/science.1150255","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1097838.560222","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1097838.553965","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,18]]}}}