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However, these patients were otherwise healthy, with normal resistance to other microbes. Their clinical status improved with age, but not due to any cellular leakiness in MyD88 deficiency. The MyD88-dependent TLRs and IL-1Rs are therefore essential for protective immunity to a small number of pyogenic bacteria, but redundant for host defense to most natural infections.<\/jats:p>","DOI":"10.1126\/science.1158298","type":"journal-article","created":{"date-parts":[[2008,7,31]],"date-time":"2008-07-31T17:08:29Z","timestamp":1217524109000},"page":"691-696","source":"Crossref","is-referenced-by-count":716,"title":["Pyogenic Bacterial Infections in Humans with MyD88 Deficiency"],"prefix":"10.1126","volume":"321","author":[{"given":"Horst","family":"von Bernuth","sequence":"first","affiliation":[{"name":"Human Genetics of Infectious Diseases, INSERM U550, Paris, France."},{"name":"Paris Descartes University, France."},{"name":"Study Center of Primary Immunodeficiencies, Assistance Publique Ho\u0302pitaux de Paris, Necker Hospital, Paris, France."},{"name":"Baylor Institute for Immunology Research, Dallas, TX 75204, USA."},{"name":"Baylor University, Waco, TX 76798, 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S. Hirsch, B. Zisman, A. C. Allison, J. Immunol.104, 1160 (1970).","journal-title":"J. Immunol."},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030026"},{"key":"e_1_3_1_32_2","unstructured":"We thank the patients and their families the members of the laboratory and our collaborators A. Alcais C. Bidalled M. Courat M. N'Guyen T. Leclerc K. von Bernuth E. von Bernuth A. von Bernuth J. von Bernuth M. Gahr F. de la Rocque C. Levy A. Lecuyer M. Albert F. Barrat and R. Miller. This work was supported by grants from the INSERM Agence Nationale de la Recherche Institut des Maladies Rares Programme Hospitalier de Recherche Clinique Banque nationale de Paris Paribas Foundation and the Dana Foundation (to J.-L.C.); grants from the NIH (U19 AIO57234-02) and the Dana Foundation (to D.C.); grants from the Hungarian Research Fund (to L.M.); and grants FIS\/PI060241 (to J.Y.) and FIS\/PI070329 (to M.J.) from Spain's Ministry of Health. H.v.B. was supported by the Deutsche Forschungsgemeinschaft Legs Poix and University San Rafaele Salute. J.-L.C. is an International Scholar of the Howard Hughes Medical Institute. The authors declare that they have no financial conflict of interest. The microarray data used in this study have been deposited in NCBI's Gene Expression Omnibus (GEO) with the accession number GSE 12124."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1158298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:07:22Z","timestamp":1704859642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1158298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":31,"journal-issue":{"issue":"5889","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1126\/science.1158298"],"URL":"https:\/\/doi.org\/10.1126\/science.1158298","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1119814.576531","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1119814.575908","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1119814.579951","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1119814.578920","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1119814.576314","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}