{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:52:30Z","timestamp":1791489150983,"version":"4.3.4"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5891","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2008,8,15]]},"abstract":"<jats:p>Previous attempts have shown the potential of T cells in immunotherapy of cancer. Here, we report on the clinical activity of a bispecific antibody construct called blinatumomab, which has the potential to engage all cytotoxic T cells in patients for lysis of cancer cells. Doses as low as 0.005 milligrams per square meter per day in non\u2013Hodgkin's lymphoma patients led to an elimination of target cells in blood. Partial and complete tumor regressions were first observed at a dose level of 0.015 milligrams, and all seven patients treated at a dose level of 0.06 milligrams experienced a tumor regression. Blinatumomab also led to clearance of tumor cells from bone marrow and liver. T cell\u2013engaging antibodies appear to have therapeutic potential for the treatment of malignant diseases.<\/jats:p>","DOI":"10.1126\/science.1158545","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T16:44:02Z","timestamp":1218732242000},"page":"974-977","source":"Crossref","is-referenced-by-count":982,"title":["Tumor Regression in Cancer Patients by Very Low Doses of a T Cell\u2013Engaging Antibody"],"prefix":"10.1126","volume":"321","author":[{"given":"Ralf","family":"Bargou","sequence":"first","affiliation":[{"name":"Interdisciplinary Phase I\/II Unit of the University of Wu\u0308rzburg, Klinikstra\u00dfe 6-8, 97070 Wu\u0308rzburg, Germany."},{"name":"Universita\u0308tsklinikum Wu\u0308rzburg, Medizinische Klinik und Poliklinik II, Klinikstra\u00dfe 6-8, 97070 Wu\u0308rzburg, Germany."},{"name":"Micromet AG, Staffelseestra\u00dfe 2, 81477 Munich, Germany; and Micromet, Incorporated, 6707 Democracy Boulevard, Bethesda, MD 20817, USA."},{"name":"Universita\u0308tsklinikum Essen, Klinik fu\u0308r Ha\u0308matologie, Medizinische Klinik und Poliklinik, Hufelandstra\u00dfe 55, 45147 Essen, Germany."},{"name":"Universita\u0308tsklinikum Ulm, Innere Medizin III, Robert-Koch-Stra\u00dfe 8, 89081 Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Leo","sequence":"additional","affiliation":[{"name":"Interdisciplinary Phase I\/II Unit of the University of Wu\u0308rzburg, Klinikstra\u00dfe 6-8, 97070 Wu\u0308rzburg, Germany."},{"name":"Universita\u0308tsklinikum Wu\u0308rzburg, Medizinische Klinik und Poliklinik II, Klinikstra\u00dfe 6-8, 97070 Wu\u0308rzburg, Germany."},{"name":"Micromet AG, Staffelseestra\u00dfe 2, 81477 Munich, Germany; 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