{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:27:33Z","timestamp":1792146453885,"version":"4.4.0"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5890","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2008,8,8]]},"abstract":"<jats:p>At synapses between cortical pyramidal neurons and principal striatal medium spiny neurons (MSNs), postsynaptic D1 and D2 dopamine (DA) receptors are postulated to be necessary for the induction of long-term potentiation and depression, respectively\u2014forms of plasticity thought to underlie associative learning. Because these receptors are restricted to two distinct MSN populations, this postulate demands that synaptic plasticity be unidirectional in each cell type. Using brain slices from DA receptor transgenic mice, we show that this is not the case. Rather, DA plays complementary roles in these two types of MSN to ensure that synaptic plasticity is bidirectional and Hebbian. In models of Parkinson's disease, this system is thrown out of balance, leading to unidirectional changes in plasticity that could underlie network pathology and symptoms.<\/jats:p>","DOI":"10.1126\/science.1160575","type":"journal-article","created":{"date-parts":[[2008,8,7]],"date-time":"2008-08-07T16:34:33Z","timestamp":1218126873000},"page":"848-851","source":"Crossref","is-referenced-by-count":1100,"title":["Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity"],"prefix":"10.1126","volume":"321","author":[{"given":"Weixing","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA."},{"name":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Flajolet","sequence":"additional","affiliation":[{"name":"Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA."},{"name":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Greengard","sequence":"additional","affiliation":[{"name":"Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA."},{"name":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. James","family":"Surmeier","sequence":"additional","affiliation":[{"name":"Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA."},{"name":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8091209"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1919"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35092560"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.1.1"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.03.008"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2147780"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.03.001"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05506"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn832"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1632"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1972"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2007"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1749-06.2006"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4402-07.2008"},{"key":"e_1_3_1_16_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.04.010"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0280-07.2007"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.09.004"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.08.013"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.03.026"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4476-05.2005"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2000.19640527.x"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-15-05972.1997"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90168-1"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00040-5"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4853-05.2006"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03015"},{"issue":"2","key":"e_1_3_1_29_2","first-page":"S11","volume":"16","year":"2003","unstructured":"K. Dujardin, B. Laurent, Curr. Opin. Neurol.16 (suppl. 2), S11 (2003).","journal-title":"Curr. Opin. Neurol."},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4439-05.2006"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02235-X"},{"key":"e_1_3_1_32_2","unstructured":"This work was supported by NIH grants NS 34696 (D.J.S.) MH074866 (P.G. D.J.S.) and DA10044 (P.G.) and a grant from the Picower Foundation (D.J.S. P.G.). We thank Q. Ruan K. Saporito and S. Ulrich for their technical assistance; E. Ilijic for generating brain images of tyrosine hydroxylase immunoreactivity following unilateral 6-OHDA lesioning; M. Day for supplying two-photon laser scanning microscopy images; N. Spruston R. Malenka and the members of the Surmeier laboratory for helpful discussion; and N. Spruston and A. Contractor for their comments on the manuscript."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1160575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:11:58Z","timestamp":1704859918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1160575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,8]]},"references-count":31,"journal-issue":{"issue":"5890","published-print":{"date-parts":[[2008,8,8]]}},"alternative-id":["10.1126\/science.1160575"],"URL":"https:\/\/doi.org\/10.1126\/science.1160575","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1120107.575597","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1120107.576247","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1120107.576252","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,8]]}}}