{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:29:12Z","timestamp":1791221352900,"version":"4.1.0"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5913","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,1,23]]},"abstract":"<jats:p>\n            Following infection, nai\u0308ve CD8\n            <jats:sup>+<\/jats:sup>\n            T cells bearing pathogen-specific T cell receptors (TCRs) differentiate into a mixed population of short-lived effector and long-lived memory T cells to mediate an adaptive immune response. How the TCR regulates memory T cell development has remained elusive. Using a mutant TCR transgenic model, we found that point mutations in the TCR \u03b2 transmembrane domain (\u03b2TMD) impair the development and function of CD8\n            <jats:sup>+<\/jats:sup>\n            memory T cells without affecting primary effector T cell responses. Mutant T cells are deficient in polarizing the TCR and in organizing the nuclear factor \u03baB signal at the immunological synapse. Thus, effector and memory states of CD8\n            <jats:sup>+<\/jats:sup>\n            T cells are separable fates, determined by differential TCR signaling.\n          <\/jats:p>","DOI":"10.1126\/science.1163612","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T22:42:35Z","timestamp":1232664155000},"page":"502-505","source":"Crossref","is-referenced-by-count":179,"title":["Different T Cell Receptor Signals Determine CD8\n            <sup>+<\/sup>\n            Memory Versus Effector Development"],"prefix":"10.1126","volume":"323","author":[{"given":"Emma","family":"Teixeiro","sequence":"first","affiliation":[{"name":"Experimental Transplantation Immunology, Department of Biomedicine, University Hospital-Basel, Hebelstrasse 20, 4031-Basel, Switzerland."},{"name":"Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Center for Cellular and Molecular Immunology, Columbia, MO 65212, USA."},{"name":"Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55454, USA."},{"name":"Department of Immunology, Fundacio\u0301n Jime\u0301nez Di\u0301az, Avenida Reyes Cato\u0301licos 2, 28040-Madrid, Spain."},{"name":"Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905,USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Experimental Transplantation Immunology, Department of Biomedicine, University Hospital-Basel, Hebelstrasse 20, 4031-Basel, Switzerland."},{"name":"Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Center for Cellular and Molecular Immunology, Columbia, MO 65212, USA."},{"name":"Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55454, USA."},{"name":"Department of Immunology, Fundacio\u0301n Jime\u0301nez Di\u0301az, Avenida Reyes Cato\u0301licos 2, 28040-Madrid, Spain."},{"name":"Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905,USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Experimental Transplantation Immunology, Department of Biomedicine, University Hospital-Basel, Hebelstrasse 20, 4031-Basel, Switzerland."},{"name":"Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Center for Cellular and Molecular Immunology, Columbia, MO 65212, USA."},{"name":"Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55454, USA."},{"name":"Department of Immunology, Fundacio\u0301n Jime\u0301nez Di\u0301az, Avenida Reyes Cato\u0301licos 2, 28040-Madrid, Spain."},{"name":"Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905,USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam G.","family":"Schrum","sequence":"additional","affiliation":[{"name":"Experimental Transplantation Immunology, Department of Biomedicine, University Hospital-Basel, Hebelstrasse 20, 4031-Basel, Switzerland."},{"name":"Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Center for Cellular and Molecular Immunology, Columbia, MO 65212, USA."},{"name":"Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55454, USA."},{"name":"Department of Immunology, Fundacio\u0301n Jime\u0301nez Di\u0301az, Avenida Reyes Cato\u0301licos 2, 28040-Madrid, Spain."},{"name":"Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905,USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Bragado","sequence":"additional","affiliation":[{"name":"Experimental Transplantation Immunology, Department of Biomedicine, University Hospital-Basel, Hebelstrasse 20, 4031-Basel, Switzerland."},{"name":"Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Center for Cellular and Molecular Immunology, Columbia, MO 65212, USA."},{"name":"Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55454, USA."},{"name":"Department of Immunology, Fundacio\u0301n Jime\u0301nez Di\u0301az, Avenida Reyes Cato\u0301licos 2, 28040-Madrid, Spain."},{"name":"Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905,USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Jameson","sequence":"additional","affiliation":[{"name":"Experimental Transplantation Immunology, Department of Biomedicine, University Hospital-Basel, Hebelstrasse 20, 4031-Basel, Switzerland."},{"name":"Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Center for Cellular and Molecular Immunology, Columbia, MO 65212, USA."},{"name":"Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55454, USA."},{"name":"Department of Immunology, Fundacio\u0301n Jime\u0301nez Di\u0301az, Avenida Reyes Cato\u0301licos 2, 28040-Madrid, Spain."},{"name":"Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905,USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Palmer","sequence":"additional","affiliation":[{"name":"Experimental Transplantation Immunology, Department of Biomedicine, University Hospital-Basel, Hebelstrasse 20, 4031-Basel, Switzerland."},{"name":"Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Center for Cellular and Molecular Immunology, Columbia, MO 65212, USA."},{"name":"Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55454, USA."},{"name":"Department of Immunology, Fundacio\u0301n Jime\u0301nez Di\u0301az, Avenida Reyes Cato\u0301licos 2, 28040-Madrid, Spain."},{"name":"Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905,USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01139-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5408.1745"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064571"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1257"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139393"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.010"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2251"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri959"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni912"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060928"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.02.014"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02238"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/smim.1994.1049"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.014"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199903)29:03<745::AID-IMMU745>3.0.CO;2-0"},{"key":"e_1_3_2_17_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_2_18_2","unstructured":"Single-letter abbreviations for the amino acid residues are as follows: A Ala; C Cys; D Asp; E Glu; F Phe; G Gly; H His; I Ile; K Lys; L Leu; M Met; N Asn; P Pro; Q Gln; R Arg; S Ser; T Thr; V Val; W Trp; and Y Tyr."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90169-4"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124228"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141548"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni802"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1418"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.6.3821"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(02)00260-2"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00237-1"},{"key":"e_1_3_2_27_2","unstructured":"We thank D. Roubaty B. Hausmann V. J\u00e4ggin G. E. Fernandez H. Karauzum M. Schmaler and Z. Rajacic for technical assistance; R. Landmann-Suter for technical advice; and C. Pernas Pernas for helpful discussion. This work was supported by Mission Enhancement Program University of Missouri (E.T. and M.A.D.) fellowships from the Fundaci\u00f3n Ram\u00f3n Areces Spain (E.T.) the American Cancer Society (S.E.H.) the Cancer Research Institute (M.A.D.) the Spanish Ministry of Science and Education (MEC) (BFU 2005-02807) (R.B.) Novartis Roche Sybilla (EUFP7) and the Swiss National Science Foundation (E.P.)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1163612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T08:47:37Z","timestamp":1704876457000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1163612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,23]]},"references-count":26,"journal-issue":{"issue":"5913","published-print":{"date-parts":[[2009,1,23]]}},"alternative-id":["10.1126\/science.1163612"],"URL":"https:\/\/doi.org\/10.1126\/science.1163612","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,23]]}}}